carbonic acid 4-(2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-2-octylcarbamoyl-ethyl)-phenyl ester pyridin-4-ylmethyl ester

Base Information

Chemical Name:carbonic acid 4-(2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-2-octylcarbamoyl-ethyl)-phenyl ester pyridin-4-ylmethyl ester
CAS No.:325464-66-2
Molecular Formula:C₃₇H₅₄N₄O₇
Molecular Weight:666.858
Hs Code.:

carbonic acid 4-(2-{[4-(<i>tert</i>-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-2-octylcarbamoyl-ethyl)-phenyl ester pyridin-4-ylmethyl ester

Synonyms:carbonic acid 4-(2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-2-octylcarbamoyl-ethyl)-phenyl ester pyridin-4-ylmethyl ester

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Chemical Property of carbonic acid 4-(2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-2-octylcarbamoyl-ethyl)-phenyl ester pyridin-4-ylmethyl ester

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Technology Process of carbonic acid 4-(2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-2-octylcarbamoyl-ethyl)-phenyl ester pyridin-4-ylmethyl ester

There total 4 articles about carbonic acid 4-(2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-2-octylcarbamoyl-ethyl)-phenyl ester pyridin-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 27687-14-5
trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid

: Carbonic acid 4-((S)-2-amino-2-octylcarbamoyl-ethyl)-phenyl ester pyridin-4-ylmethyl ester

: 325464-66-2
carbonic acid 4-(2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-2-octylcarbamoyl-ethyl)-phenyl ester pyridin-4-ylmethyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 15h;
DOI:10.1248/cpb.48.1964

Reference yield:

: 111-86-4
n-Octylamine

: 325464-66-2
carbonic acid 4-(2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-2-octylcarbamoyl-ethyl)-phenyl ester pyridin-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / tetrahydrofuran / 0 - 20 °C

2: TFA; anisole

3: 52 percent / DIPEA; BOP / acetonitrile / 15 h / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1248/cpb.48.1964

Reference yield:

: carbonic acid 4-(2-tert-butoxycarbonylamino-3-isobutoxycarbonyloxy-3-oxo-propyl)-phenyl ester pyridin-4-ylmethyl ester

: 325464-66-2
carbonic acid 4-(2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-2-octylcarbamoyl-ethyl)-phenyl ester pyridin-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / tetrahydrofuran / 0 - 20 °C

2: TFA; anisole

3: 52 percent / DIPEA; BOP / acetonitrile / 15 h / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; methoxybenzene; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1248/cpb.48.1964