(4S,5R)-3,3-Dichloro-4-(chloro-difluoro-methyl)-5-p-tolylsulfanyl-dihydro-furan-2-one

Base Information

Chemical Name:(4S,5R)-3,3-Dichloro-4-(chloro-difluoro-methyl)-5-p-tolylsulfanyl-dihydro-furan-2-one
CAS No.:220178-53-0
Molecular Formula:C₁₂H₉Cl₃F₂O₂S
Molecular Weight:361.624
Hs Code.:

Synonyms:(4S,5R)-3,3-Dichloro-4-(chloro-difluoro-methyl)-5-p-tolylsulfanyl-dihydro-furan-2-one

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Chemical Property of (4S,5R)-3,3-Dichloro-4-(chloro-difluoro-methyl)-5-p-tolylsulfanyl-dihydro-furan-2-one

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Technology Process of (4S,5R)-3,3-Dichloro-4-(chloro-difluoro-methyl)-5-p-tolylsulfanyl-dihydro-furan-2-one

There total 3 articles about (4S,5R)-3,3-Dichloro-4-(chloro-difluoro-methyl)-5-p-tolylsulfanyl-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 76-02-8
trifluoroacetyl chloride

: 1-((E)-3-Chloro-3,3-difluoro-prop-1-ene-1-sulfinyl)-4-methyl-benzene

: 220178-53-0
(4S,5R)-3,3-Dichloro-4-(chloro-difluoro-methyl)-5-p-tolylsulfanyl-dihydro-furan-2-one

Guidance literature:: With copper(l) chloride; zinc; In tetrahydrofuran; at 0 ℃;
DOI:10.1002/(sici)1099-0690(199901)1999:1<111::aid-ejoc111>3.0.co;2-5

Reference yield:

: 1-Chloro-1,1-difluoro-3-(toluene-4-sulfinyl)-propan-2-ol

: 220178-53-0
(4S,5R)-3,3-Dichloro-4-(chloro-difluoro-methyl)-5-p-tolylsulfanyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / Bu₄NHSO₄, 30percent aq. NaOH, methanesulfonyl chloride / CH₂Cl₂ / 1.) 30 min, 0 deg C, 2.) 1 h, RT

2: 60 percent / zinc dust, CuCl / tetrahydrofuran / 0 °C

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; methanesulfonyl chloride; copper(l) chloride; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1002/(sici)1099-0690(199901)1999:1<111::aid-ejoc111>3.0.co;2-5

Reference yield:

: 1-Chloro-1,1-difluoro-3-(toluene-4-sulfinyl)-propan-2-one

: 220178-53-0
(4S,5R)-3,3-Dichloro-4-(chloro-difluoro-methyl)-5-p-tolylsulfanyl-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / NaBH₄ / ethanol / 0.5 h / 0 °C

2: 72 percent / Bu₄NHSO₄, 30percent aq. NaOH, methanesulfonyl chloride / CH₂Cl₂ / 1.) 30 min, 0 deg C, 2.) 1 h, RT

3: 60 percent / zinc dust, CuCl / tetrahydrofuran / 0 °C

With sodium hydroxide; sodium tetrahydroborate; tetra(n-butyl)ammonium hydrogensulfate; methanesulfonyl chloride; copper(l) chloride; zinc; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1002/(sici)1099-0690(199901)1999:1<111::aid-ejoc111>3.0.co;2-5