(+/-)-N-benzyloxycarbonyl-N-methyl-glycine-(trans-2-hydroxy-cyclohexylamide)

Base Information

• Chemical Name: (+/-)-N-benzyloxycarbonyl-N-methyl-glycine-(trans-2-hydroxy-cyclohexylamide)
• CAS No.: 101591-07-5
• Molecular Formula: C₁₇H₂₄N₂O₄
• Molecular Weight: 320.389
• Mol file: 101591-07-5.mol

Synonyms:(+/-)-N-benzyloxycarbonyl-N-methyl-glycine-(trans-2-hydroxy-cyclohexylamide)

Chemical Property of (+/-)-N-benzyloxycarbonyl-N-methyl-glycine-(trans-2-hydroxy-cyclohexylamide)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N-benzyloxycarbonyl-N-methyl-glycine-(trans-2-hydroxy-cyclohexylamide)

There total 4 articles about (+/-)-N-benzyloxycarbonyl-N-methyl-glycine-(trans-2-hydroxy-cyclohexylamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-trans-2-aminocyclohexanol (931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5,931-15-7) + N-benzyloxycarbonyl-N-methyl-glycine cyanomethyl ester (100796-14-3) → (+/-)-N-benzyloxycarbonyl-N-methyl-glycine-(trans-2-hydroxy-cyclohexylamide) (101591-07-5)

Guidance literature:

With triethylamine;

DOI:10.1002/hlca.19590420523

Reference yield:

N-(Benzyloxycarbonyl)sarcosine (39608-31-6) → (+/-)-N-benzyloxycarbonyl-N-methyl-glycine-(cis-2-hydroxy-cyclohexylamide) (101591-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; diethyl ether

With diethyl ether; ethanol;

DOI:10.1002/hlca.19590420523

Reference yield:

N-(Benzyloxycarbonyl)sarcosine (39608-31-6) → (+/-)-N-benzyloxycarbonyl-N-methyl-glycine-(trans-2-hydroxy-cyclohexylamide) (101591-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; ethyl acetate

2: triethylamine

With ethyl acetate; triethylamine;

DOI:10.1002/hlca.19590420523

upstream raw materials:

Cbz-Sar-OMe

cis-2-amino-cyclohexanol-⁽¹⁾

N-(Benzyloxycarbonyl)sarcosine

(+/-)-trans-2-aminocyclohexanol