glycine, N-methyl-N-[(phenylmethoxy)carbonyl]-

Base Information

• Chemical Name: glycine, N-methyl-N-[(phenylmethoxy)carbonyl]-
• CAS No.: 39608-31-6
• Deprecated CAS: 860641-69-6
• Molecular Formula: C11H13NO4
• Molecular Weight: 223.229
• Hs Code.: 2922509090
• NSC Number: 97943
• UNII: T3ZZ4C081J
• DSSTox Substance ID: DTXSID2068187
• Nikkaji Number: J308.251B
• Wikidata: Q72442045
• Mol file: 39608-31-6.mol

Synonyms:39608-31-6;Z-SAR-OH;Cbz-Sar-OH;glycine, N-methyl-N-[(phenylmethoxy)carbonyl]-;N-(Benzyloxycarbonyl)sarcosine;Z-Sarcosine;2-(((Benzyloxy)carbonyl)(methyl)amino)acetic acid;(Carbobenzoxy)sarcosine;N-CBZ-sarcosine;N-(Carbobenzoxy)sarcosine;(Benzyloxycarbonyl)sarcosine;N-[(benzyloxy)carbonyl]-N-methylglycine;2-[methyl(phenylmethoxycarbonyl)amino]acetic acid;N-Carbobenzoxysarcosine;N-Cbz-N-methylglycine;N-Methyl-N-((phenylmethoxy)carbonyl)glycine;Glycine, N-methyl-N-((phenylmethoxy)carbonyl)-;NSC 97943;T3ZZ4C081J;MFCD00021747;NSC-97943;N-Methyl-N-[(phenylmethoxy)carbonyl]glycine;2-((benzyloxycarbonyl)(methyl)amino)acetic acid;N-((Benzyloxy)carbonyl)-N-methylglycine;2-[(benzyloxycarbonyl)(methyl)amino]acetic acid;Z-N-Me-Gly-OH;2-{[(benzyloxy)carbonyl](methyl)amino}acetic acid;Cbz-Sarcosine;NSC97943;N-carbobenzoxy-sarcosine;Z-Sar-OH, AldrichCPR;benzyloxycarbonyl-sarcosine;N-benzyloxycarbonylsarcosine;N-benzyloxycarbonyl-sarcosine;NCIOpen2_006575;UNII-T3ZZ4C081J;SCHEMBL316882;N-Carbobenzoxy-N-methylglycine;DTXSID2068187;N-phenylmethoxycarbonyl-sarcosine;N-(Phenylmethoxycarbonyl)sarcosine;n-benzyloxycarbonyl-n-methylglycine;N-alpha-Benzyloxycarbonyl-sarcosine;SARCOSINE,N-BENZYLOXYCARBONYL;STK030794;N-(benzyloxycarbonyl)-N-methylglycine;AKOS000164170;AM82641;CS-W014233;HY-W013517;DS-15145;SY051393;benzyl-N-(carboxymethyl)-N-methylcarbamate;(Benzyloxycarbonyl-methyl-amino)-acetic acid;C2848;FT-0656638;2-[Benzyloxycarbonyl(methyl)amino]acetic acid;N-methyl-N-[(phenylmethoxy)carbonyl]-glycine;SARCOSINE, N-CARBOXY-, N-BENZYL ESTER;EN300-121152;O10438;[[(Benzyloxy)carbonyl](methyl)amino]acetic acid;A824645;J-300364;Q-101728;((BENZYLOXYCARBONYL)(METHYL)AMINO)ACETIC ACID;2-[benzyloxycarbonyl(methyl)amino]acetic acid

Chemical Property of glycine, N-methyl-N-[(phenylmethoxy)carbonyl]-

Chemical Property:

• Vapor Pressure: 1.23E-06mmHg at 25°C
• Melting Point: 58-59 °C
• Refractive Index: 1.553
• Boiling Point: 385.6 °C at 760 mmHg
• PKA: 4.01±0.10(Predicted)
• Flash Point: 187 °C
• PSA: 66.84000
• Density: 1.26 g/cm³
• LogP: 1.33960
• Storage Temp.: Store at RT.
• Solubility.: soluble in Methanol
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 223.08445790
• Heavy Atom Count: 16
• Complexity: 248

Purity/Quality:

98% ^*data from raw suppliers

Z-N-methylglycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-51

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CC(=O)O)C(=O)OCC1=CC=CC=C1

Technology Process of glycine, N-methyl-N-[(phenylmethoxy)carbonyl]-

There total 13 articles about glycine, N-methyl-N-[(phenylmethoxy)carbonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

sarcosine (107-97-1,25951-24-0) + benzyl chloroformate (501-53-1,94274-21-2) → N-(Benzyloxycarbonyl)sarcosine (39608-31-6)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 20 ℃;

DOI:10.1016/j.bmc.2004.10.004

Reference yield: 100.0%

N-(tert-butoxycarbonyl)sarcosine (13734-36-6) + benzyl chloroformate (501-53-1,94274-21-2) → N-(Benzyloxycarbonyl)sarcosine (39608-31-6)

Guidance literature:

N-(tert-butoxycarbonyl)sarcosine; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;

benzyl chloroformate; With sodium hydroxide; In water; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.3390/molecules25092153

Reference yield: 90.0%

N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) + sarcosine (107-97-1,25951-24-0) → N-(Benzyloxycarbonyl)sarcosine (39608-31-6)

Guidance literature:

With triethylamine; In water; acetonitrile; at 20 ℃; for 96h;

DOI:10.1021/jm201480u

upstream raw materials:

sarcosine

benzyl chloroformate

phenylmethyl 5-oxo-1,3-oxazolidine-3-carboxylate

phenyl chloroformate

Downstream raw materials:

Cbz-Sar-OMe

sarcosine-N-carboxyanhydride

N-benzyloxycarbonyl-N-methyl-glycine benzylamide

N-(N-benzyloxycarbonyl-N-methyl-glycyl)-L-tyrosine ethyl ester