N-[2-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]-METHANESULFONAMIDE

Base Information

Chemical Name:N-[2-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]-METHANESULFONAMIDE
CAS No.:910486-35-0
Molecular Formula:C₁₇H₂₃N₃O₂S
Molecular Weight:333.455
Hs Code.:

Synonyms:N-[2-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]-METHANESULFONAMIDE

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Chemical Property of N-[2-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]-METHANESULFONAMIDE

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Technology Process of N-[2-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]-METHANESULFONAMIDE

There total 4 articles about N-[2-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]-METHANESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 910486-34-9
N-(6-acetyl-2-methylpyridin-3-yl)methanesulfonamide

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 910486-35-0
N-[2-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]-METHANESULFONAMIDE

Guidance literature:: N-(6-acetyl-2-methylpyridin-3-yl)methanesulfonamide; (R)-1-phenyl-ethyl-amine; With titanium tetrachloride; triethylamine; In dichloromethane; at 20 ℃; for 17h;

With hydrogen; nickel; In ethanol; dichloromethane; at 20 ℃; under 3162.96 Torr;

Reference yield:

: 164666-68-6
3-amino-6-chloro-2-methylpyridine

: 910486-35-0
N-[2-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]-METHANESULFONAMIDE

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 1 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

3.1: diethyl ether; tetrahydrofuran / 0.5 h / 100 °C / Microwave irradiation

3.2: Cooling with ice

4.1: triethylamine; titanium tetrachloride / dichloromethane / 17 h / 20 °C / Inert atmosphere

4.2: Raney-Ni / 5 h / 20 °C / 3162.96 Torr

With pyridine; titanium tetrachloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 910486-32-7
N-(6-chloro-2-methylpyridin-3-yl)methanesulfonamide

: 910486-35-0
N-[2-METHYL-6-((1R)-1-{[(1R)-1-PHENYLETHYL]AMINO}ETHYL)PYRIDIN-3-YL]-METHANESULFONAMIDE

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

2.1: diethyl ether; tetrahydrofuran / 0.5 h / 100 °C / Microwave irradiation

2.2: Cooling with ice

3.1: triethylamine; titanium tetrachloride / dichloromethane / 17 h / 20 °C / Inert atmosphere

3.2: Raney-Ni / 5 h / 20 °C / 3162.96 Torr

With titanium tetrachloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;