3-[N-[(E)-3-(6-acetylaminopyridin-3-yl)acryloylglycyl]-N-methylamino]-1-hydroxymethyl-2,6-dimethylbenzene

Base Information

Chemical Name:3-[N-[(E)-3-(6-acetylaminopyridin-3-yl)acryloylglycyl]-N-methylamino]-1-hydroxymethyl-2,6-dimethylbenzene
CAS No.:174298-74-9
Molecular Formula:C₂₂H₂₆N₄O₄
Molecular Weight:410.473
Hs Code.:

Synonyms:3-[N-[(E)-3-(6-acetylaminopyridin-3-yl)acryloylglycyl]-N-methylamino]-1-hydroxymethyl-2,6-dimethylbenzene

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Chemical Property of 3-[N-[(E)-3-(6-acetylaminopyridin-3-yl)acryloylglycyl]-N-methylamino]-1-hydroxymethyl-2,6-dimethylbenzene

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Technology Process of 3-[N-[(E)-3-(6-acetylaminopyridin-3-yl)acryloylglycyl]-N-methylamino]-1-hydroxymethyl-2,6-dimethylbenzene

There total 11 articles about 3-[N-[(E)-3-(6-acetylaminopyridin-3-yl)acryloylglycyl]-N-methylamino]-1-hydroxymethyl-2,6-dimethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 174298-73-8
3-[N-[(E)-3-(6-Acetylaminopyridin-3-yl)acryloylglycyl]-N-methylamino]-1-(tert-butyldiphenylsilyloxymethyl)-2,6-dimethylbenzene

: 174298-74-9
3-[N-[(E)-3-(6-acetylaminopyridin-3-yl)acryloylglycyl]-N-methylamino]-1-hydroxymethyl-2,6-dimethylbenzene

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1021/jm980300f

Reference yield:

: 62285-58-9
2,6-dimethylbenzyl alcohol

: 174298-74-9
3-[N-[(E)-3-(6-acetylaminopyridin-3-yl)acryloylglycyl]-N-methylamino]-1-hydroxymethyl-2,6-dimethylbenzene

Guidance literature:: Multi-step reaction with 10 steps

1: 98.2 percent / DMAP / 5 h / 70 °C

2: 94.3 percent / Cu(NO₃)2*3H₂O, Ac₂O, AcOH / 1 h / 0 - 20 °C

3: 1 N NaOH / methanol

4: imidazole / dimethylformamide / 3 h / Ambient temperature

5: FeCl₃*6H₂O, C, NH₂-NH₂*H₂O / methanol; H₂O / 5 h / 70 °C

6: Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

7: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

8: NH₂-NH₂*H₂O / ethanol / 1 h / Heating

9: WSCD*HCl, HOBt / dimethylformamide / 2 h / Ambient temperature

10: TBAF / tetrahydrofuran / 1 h / Ambient temperature

With 1H-imidazole; dmap; sodium hydroxide; WSCD*HCl; tetrabutyl ammonium fluoride; acetic anhydride; iron(III) chloride; sodium hydride; benzotriazol-1-ol; copper(II) nitrate; hydrazine hydrate; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm980300f

Reference yield:

: 62346-87-6
2,6-dimethylbenzyl acetate

: 174298-74-9
3-[N-[(E)-3-(6-acetylaminopyridin-3-yl)acryloylglycyl]-N-methylamino]-1-hydroxymethyl-2,6-dimethylbenzene

Guidance literature:: Multi-step reaction with 9 steps

1: 94.3 percent / Cu(NO₃)2*3H₂O, Ac₂O, AcOH / 1 h / 0 - 20 °C

2: 1 N NaOH / methanol

3: imidazole / dimethylformamide / 3 h / Ambient temperature

4: FeCl₃*6H₂O, C, NH₂-NH₂*H₂O / methanol; H₂O / 5 h / 70 °C

5: Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

6: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

7: NH₂-NH₂*H₂O / ethanol / 1 h / Heating

8: WSCD*HCl, HOBt / dimethylformamide / 2 h / Ambient temperature

9: TBAF / tetrahydrofuran / 1 h / Ambient temperature

With 1H-imidazole; sodium hydroxide; WSCD*HCl; tetrabutyl ammonium fluoride; acetic anhydride; iron(III) chloride; sodium hydride; benzotriazol-1-ol; copper(II) nitrate; hydrazine hydrate; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm980300f