2-(Boc-amino)-3-methylbutylamine

Base Information

• Chemical Name: 2-(Boc-amino)-3-methylbutylamine
• CAS No.: 871235-24-4
• Molecular Formula: C10H22N2O2
• Molecular Weight: 202.297
• Hs Code.: 2924199090
• Mol file: 871235-24-4.mol

Synonyms:2-(Boc-amino)-3-methylbutylamine;N-Boc-[1-(aMinoMethyl)-2-Methylpropyl]aMine

Chemical Property of 2-(Boc-amino)-3-methylbutylamine

Chemical Property:

• Boiling Point: 292.4±23.0 °C(Predicted)
• PKA: 12.11±0.46(Predicted)
• PSA: 67.84000
• Density: 0.961±0.06 g/cm3(Predicted)
• LogP: 2.39910

Purity/Quality:

97% ^*data from raw suppliers

tert-ButylN-(1-amino-3-methylbutan-2-yl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: tert-butyl N-(1-amino-3-methylbutan-2-yl)carbamate is a useful reagent in the preparation of pyrimidine derivatives as CCR4 antagonists.

Technology Process of 2-(Boc-amino)-3-methylbutylamine

There total 5 articles about 2-(Boc-amino)-3-methylbutylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

tert-butyl[1-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-methylbutan-2-yl]carbamate (1529801-89-5) → 2-methyl-2-propanyl (1-amino-3-methyl-2-butanyl)carbamate (871235-24-4,400652-50-8)

Guidance literature:

With amino aminoalcohol; In ethanol; for 0.75h; Reflux;

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → 2-methyl-2-propanyl (1-amino-3-methyl-2-butanyl)carbamate (871235-24-4,400652-50-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / 1,4-dioxane

2.1: tetrahydrofuran; water / 0.17 h

2.2: 12 h

3.1: triphenylphosphine / tetrahydrofuran / 0 °C / Inert atmosphere

3.2: 12 h / Heating

4.1: amino aminoalcohol / ethanol / 0.75 h / Reflux

With amino aminoalcohol; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2-methyl-2-propanyl (1-amino-3-methyl-2-butanyl)carbamate (871235-24-4,400652-50-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydroxide / 1,4-dioxane

2.1: tetrahydrofuran; water / 0.17 h

2.2: 12 h

3.1: triphenylphosphine / tetrahydrofuran / 0 °C / Inert atmosphere

3.2: 12 h / Heating

4.1: amino aminoalcohol / ethanol / 0.75 h / Reflux

With amino aminoalcohol; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

upstream raw materials:

L-valine

di-tert-butyl dicarbonate

t-Boc-L-valine

rac-tert-butyl (1-hydroxy-3-methylbutan-2-yl)carbamate

Downstream raw materials:

rac-tert-butyl {1-[({6-chloro-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

rac-tert-butyl {1-[({8-[(2,6-difluorobenzyl)oxy]-2,6-dimethylimidazo[1,2-a]pyridin-3-yl}carbonyl)amino]-3-methylbutan-2-yl}carbamate

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