(S)-1-cyclopropyl-3-(3-fluoro-4-(2-(5-((1-methoxypropan-2-ylamino)methyl)-pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

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Chemical Name:(S)-1-cyclopropyl-3-(3-fluoro-4-(2-(5-((1-methoxypropan-2-ylamino)methyl)-pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea
CAS No.:1187212-75-4
Molecular Formula:C₂₇H₂₈FN₅O₃S
Molecular Weight:521.615
Hs Code.:

Synonyms:(S)-1-cyclopropyl-3-(3-fluoro-4-(2-(5-((1-methoxypropan-2-ylamino)methyl)-pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

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Chemical Property of (S)-1-cyclopropyl-3-(3-fluoro-4-(2-(5-((1-methoxypropan-2-ylamino)methyl)-pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

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Technology Process of (S)-1-cyclopropyl-3-(3-fluoro-4-(2-(5-((1-methoxypropan-2-ylamino)methyl)-pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

There total 7 articles about (S)-1-cyclopropyl-3-(3-fluoro-4-(2-(5-((1-methoxypropan-2-ylamino)methyl)-pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1187213-95-1
1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea

: 37143-54-7,99636-38-1,123410-24-2,99636-32-5
(1S)-2-methoxy-1-methylethylamine

: 1187212-75-4
(S)-1-cyclopropyl-3-(3-fluoro-4-(2-(5-((1-methoxypropan-2-ylamino)methyl)-pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: 1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea; (1S)-2-methoxy-1-methylethylamine; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In dichloromethane; water;

With sodium hydroxide; In water; for 0.5h; pH=12;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1187212-75-4
(S)-1-cyclopropyl-3-(3-fluoro-4-(2-(5-((1-methoxypropan-2-ylamino)methyl)-pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: camphor-10-sulfonic acid / toluene / 0.83 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.33 h / -10 - -5 °C

2.2: 1.58 h / -10 - 20 °C

2.3: 2 h / Reflux

3.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h

3.2: 1.5 h / 100 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C

4.2: 0 - 20 °C

5.1: water; trifluoroacetic acid / acetone / 6 h / Reflux

6.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C / Inert atmosphere

6.3: 0.5 h / pH 12

With n-butyllithium; potassium tert-butylate; water; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; camphor-10-sulfonic acid; In tetrahydrofuran; hexanes; dichloromethane; dimethyl sulfoxide; acetone; toluene;

Reference yield:

: 1123838-05-0
2-(5-(1,3-dioxan-2-yl)pyridin-2-yl)-7-chlorothieno[3,2-b]pyridine

: 1187212-75-4
(S)-1-cyclopropyl-3-(3-fluoro-4-(2-(5-((1-methoxypropan-2-ylamino)methyl)-pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h

1.2: 1.5 h / 100 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C

2.2: 0 - 20 °C

3.1: water; trifluoroacetic acid / acetone / 6 h / Reflux

4.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C / Inert atmosphere

4.3: 0.5 h / pH 12

With potassium tert-butylate; water; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetone;