(S)-N-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-N-(1-methoxypropan-2-yl)acetamide

Base Information

Chemical Name:(S)-N-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-N-(1-methoxypropan-2-yl)acetamide
CAS No.:1187212-76-5
Molecular Formula:C₂₉H₃₀FN₅O₄S
Molecular Weight:563.653
Hs Code.:

Synonyms:(S)-N-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-N-(1-methoxypropan-2-yl)acetamide

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Chemical Property of (S)-N-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-N-(1-methoxypropan-2-yl)acetamide

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Technology Process of (S)-N-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-N-(1-methoxypropan-2-yl)acetamide

There total 7 articles about (S)-N-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-N-(1-methoxypropan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1187212-75-4
(S)-1-cyclopropyl-3-(3-fluoro-4-(2-(5-((1-methoxypropan-2-ylamino)methyl)-pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea

: 108-24-7
acetic anhydride

: 1187212-76-5
(S)-N-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-N-(1-methoxypropan-2-yl)acetamide

Guidance literature:: (S)-1-cyclopropyl-3-(3-fluoro-4-(2-(5-((1-methoxypropan-2-ylamino)methyl)-pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)urea; acetic anhydride; at 20 ℃; for 48h;

With sodium hydroxide; In water; ethyl acetate;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1187212-76-5
(S)-N-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-N-(1-methoxypropan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: camphor-10-sulfonic acid / toluene / 0.83 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.33 h / -10 - -5 °C

2.2: 1.58 h / -10 - 20 °C

2.3: 2 h / Reflux

3.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h

3.2: 1.5 h / 100 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C

4.2: 0 - 20 °C

5.1: water; trifluoroacetic acid / acetone / 6 h / Reflux

6.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C / Inert atmosphere

6.3: 0.5 h / pH 12

7.1: 48 h / 20 °C

With n-butyllithium; potassium tert-butylate; water; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; camphor-10-sulfonic acid; In tetrahydrofuran; hexanes; dichloromethane; dimethyl sulfoxide; acetone; toluene;

Reference yield:

: 1123838-05-0
2-(5-(1,3-dioxan-2-yl)pyridin-2-yl)-7-chlorothieno[3,2-b]pyridine

: 1187212-76-5
(S)-N-((6-(7-(4-(3-cyclopropylureido)-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-N-(1-methoxypropan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h

1.2: 1.5 h / 100 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C

2.2: 0 - 20 °C

3.1: water; trifluoroacetic acid / acetone / 6 h / Reflux

4.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C / Inert atmosphere

4.3: 0.5 h / pH 12

5.1: 48 h / 20 °C

With potassium tert-butylate; water; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetone;