tert-butyl ({(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-2-yl}methyl)carbamate

Base Information

Chemical Name:tert-butyl ({(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-2-yl}methyl)carbamate
CAS No.:248914-23-0
Molecular Formula:C₁₉H₃₀N₂O₃
Molecular Weight:334.459
Hs Code.:

Synonyms:tert-butyl ({(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-2-yl}methyl)carbamate

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Chemical Property of tert-butyl ({(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-2-yl}methyl)carbamate

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Technology Process of tert-butyl ({(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-2-yl}methyl)carbamate

There total 1 articles about tert-butyl ({(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-2-yl}methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 153918-98-0
(2R)-2-<(2S)-2-(aminomethyl)piperidin-1-yl>-2-phenylethanol

: 248914-23-0
tert-butyl ({(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-2-yl}methyl)carbamate

Guidance literature:: In 1,4-dioxane; water; at 20 ℃; for 0.25h;
DOI:10.3987/com-99-8544

Reference yield: 87.0%

: 248914-23-0
tert-butyl ({(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-2-yl}methyl)carbamate

: 139004-93-6
(S)-tert-butyl (piperidin-2-ylmethyl)carbamate

Guidance literature:: tert-butyl ({(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-2-yl}methyl)carbamate; With hydrogen; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; at 40 ℃; for 21h; under 900.09 - 975.098 Torr;

With sodium hydroxide; In water; pH=> 10;

Reference yield:

: 248914-23-0
tert-butyl ({(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]piperidin-2-yl}methyl)carbamate

: 248914-24-1
tert-butyl {[(2S)-1-(chloroacetyl)piperidin-2-yl]methyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / hydrogen / Pd/C / methanol / 4 h

2: 87 percent / aq. NaOH / CH₂Cl₂ / 3 h / 20 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; 1: Hydrogenolysis / 2: Acylation;
DOI:10.3987/com-99-8544