8-methoxy-5-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Base Information

Chemical Name:8-methoxy-5-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
CAS No.:634195-42-9
Molecular Formula:C₁₄H₁₁F₃N₄O
Molecular Weight:308.263
Hs Code.:

8-methoxy-5-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-<i>a</i>]pyridin-2-ylamine

Synonyms:8-methoxy-5-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-methoxy-5-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

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Technology Process of 8-methoxy-5-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

There total 4 articles about 8-methoxy-5-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 492468-97-0
8-methoxy-5-iodo-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine

: 634195-42-9
8-methoxy-5-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 80 ℃; for 1.5h;
DOI:10.1055/s-2003-40874

Reference yield:

: 10201-71-5
3-methoxypyridin-2-amine

: 634195-42-9
8-methoxy-5-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / dioxane

2: 78 percent / NH₂OH; DMAP / methanol; ethanol

3: 49 percent / KIO₃; H₂SO₄ / 4 h / 120 °C

4: Pd(dppf)*DCM; Na₂CO₃ / dioxane / 80 °C

With dmap; potassium iodate; Pd(dppf)*DCM; sulfuric acid; hydroxylamine; sodium carbonate; In 1,4-dioxane; methanol; ethanol; 4: Suzuki coupling;
DOI:10.2533/000942904777677542

Reference yield:

: 175965-58-9
ethyl N-[(3-methoxypyridin-2-yl)carbamothioyl]carbamate

: 634195-42-9
8-methoxy-5-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / NH₂OH; DMAP / methanol; ethanol

2: 49 percent / KIO₃; H₂SO₄ / 4 h / 120 °C

3: Pd(dppf)*DCM; Na₂CO₃ / dioxane / 80 °C

With dmap; potassium iodate; Pd(dppf)*DCM; sulfuric acid; hydroxylamine; sodium carbonate; In 1,4-dioxane; methanol; ethanol; 3: Suzuki coupling;
DOI:10.2533/000942904777677542