2,6-dichloro-N-(2-((1-ethyl-1H-pyrazol-4-yl)amino)pyridin-4-yl)benzamide

Base Information

• Chemical Name: 2,6-dichloro-N-(2-((1-ethyl-1H-pyrazol-4-yl)amino)pyridin-4-yl)benzamide
• CAS No.: 1258293-06-9
• Molecular Formula: C₁₇H₁₅Cl₂N₅O
• Molecular Weight: 376.245

Synonyms:2,6-dichloro-N-(2-((1-ethyl-1H-pyrazol-4-yl)amino)pyridin-4-yl)benzamide

Chemical Property of 2,6-dichloro-N-(2-((1-ethyl-1H-pyrazol-4-yl)amino)pyridin-4-yl)benzamide

Chemical Property:

Purity/Quality:

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Technology Process of 2,6-dichloro-N-(2-((1-ethyl-1H-pyrazol-4-yl)amino)pyridin-4-yl)benzamide

There total 4 articles about 2,6-dichloro-N-(2-((1-ethyl-1H-pyrazol-4-yl)amino)pyridin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-ethyl-1H-pyrazol-4-amine (876343-24-7) + N-(2-bromopyridin-4-yl)-2,6-dichlorobenzamide (1258298-00-8) → 2,6-dichloro-N-(2-((1-ethyl-1H-pyrazol-4-yl)amino)pyridin-4-yl)benzamide (1258293-06-9)

Guidance literature:

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 150 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere; Sealed tube;

DOI:10.1016/j.ejmech.2013.03.070

Reference yield:

2,6-Dichlorobenzoyl chloride (4659-45-4) → 2,6-dichloro-N-(2-((1-ethyl-1H-pyrazol-4-yl)amino)pyridin-4-yl)benzamide (1258293-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

2.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.33 h / 150 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With palladium diacetate; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil; 2.1: |Buchwald-Hartwig Coupling;

DOI:10.1016/j.ejmech.2013.03.070

Reference yield:

2-bromo-4-aminopyridine (7598-35-8) → 2,6-dichloro-N-(2-((1-ethyl-1H-pyrazol-4-yl)amino)pyridin-4-yl)benzamide (1258293-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

2.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 0.33 h / 150 °C / Microwave irradiation; Inert atmosphere; Sealed tube

With palladium diacetate; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil; 2.1: |Buchwald-Hartwig Coupling;

DOI:10.1016/j.ejmech.2013.03.070

upstream raw materials:

2,6-Dichlorobenzoyl chloride

2-bromo-4-aminopyridine

1-ethyl-1H-pyrazol-4-amine

N-(2-bromopyridin-4-yl)-2,6-dichlorobenzamide

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