Paromomycin

Base Information Edit

Chemical Name:Paromomycin
CAS No.:7542-37-2
Deprecated CAS:11002-84-9,10010-79-4,11002-85-0,11021-48-0,1389-70-4,1391-98-6,25329-75-3,59-04-1,11035-13-5,1390-73-4,10010-79-4,11002-85-0,11021-48-0,11035-13-5,1389-70-4,1390-73-4,1391-98-6,25329-75-3,59-04-1
Molecular Formula:C23H45 N5 O14
Molecular Weight:615.635
Hs Code.:
European Community (EC) Number:231-423-0,215-031-7
UNII:61JJC8N5ZK
DSSTox Substance ID:DTXSID8023424
Nikkaji Number:J8.952D
Wikipedia:Paromomycin
Wikidata:Q415625
NCI Thesaurus Code:C61878
RXCUI:7934
Metabolomics Workbench ID:43550
ChEMBL ID:CHEMBL370143
Mol file:7542-37-2.mol

Synonyms:Aminosidine;beta-D-Glucopyranosyl-Isomer Paromomycin;Catenulin;Estomycin;Gabbromycin;Humatin;Hydroxymycin;Neomycin E;Paramomycin;Paromomycin;Paromomycin I;Paromomycin Phosphate;Paromomycin Sulfate;Paromomycin Sulfate (1:1);Paromomycin Sulfate (2:5);Paromomycin, beta D Glucopyranosyl Isomer;Paromomycin, beta-D-Glucopyranosyl-Isomer

Suppliers and Price of Paromomycin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 26 raw suppliers

Chemical Property of Paromomycin Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.7500 (estimate)
Boiling Point:939.8ºC at 760 mmHg
PKA:12.93±0.70(Predicted)
Flash Point:522.2ºC
PSA：347.32000
Density:1.64g/cm3
LogP:-5.36020
XLogP3:-8.7
Hydrogen Bond Donor Count:13
Hydrogen Bond Acceptor Count:19
Rotatable Bond Count:9
Exact Mass:615.29630113
Heavy Atom Count:42
Complexity:870

Purity/Quality:: 99%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
Isomeric SMILES:C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N
Recent ClinicalTrials:Miltefosine/Paromomycin Phase III Trial for Treatment of Primary Visceral Leishmaniasis (VL) Patients in Eastern Africa
Recent EU Clinical Trials:Controlled, randomized trial, comparing the efficacy of paromomicin and
Description Paromomycin is recommended for treatment of acute and chronic forms of intestinal amobiasis, as well as for treating intestinal bacteria Salmonella and Shigella. Synonyms of this drug are aminosidine, catenulin, crestomycin, hydroxymycin, monomycin, zygomycyn, and others.
Indications The antibacterial activity and indications for using paromomycin are analogous to those of neomycin. In addition, it is recommended for treating severe and chronic forms of gastric amebiasis. Synonyms of this drug are aminosidine, catenulin, crestomycin, hydroxymycin, monomycin, zygomycyn, and others.
Clinical Use Intestinal amebiasis (oral) Cutaneous leishmaniasis (topical) and visceral leishmaniasis (intramuscular) Nitroimidazole-resistant trichomoniasis (topical) Its antiprotozoal activity has attracted some attention, but it has largely been superseded by more active and less toxic compounds. Success in treating nitroimidazole-resistant trichomoniasis with topical paromomycin has been reported. Trials in India and East Africa of parenteral paromomycin alone, or in combination with sodium stibogluconate, for treatment of visceral leishmaniasis have shown promising results.

Technology Process of Paromomycin

There total 2 articles about Paromomycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: