2-amino-1,2-bis(4-isopropoxy-3-methoxyphenyl)ethanone trifluoroacetate

Base Information

Chemical Name:2-amino-1,2-bis(4-isopropoxy-3-methoxyphenyl)ethanone trifluoroacetate
CAS No.:1333109-40-2
Molecular Formula:C₂HF₃O₂*C₂₂H₂₉NO₅
Molecular Weight:501.5
Hs Code.:

Synonyms:2-amino-1,2-bis(4-isopropoxy-3-methoxyphenyl)ethanone trifluoroacetate

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Chemical Property of 2-amino-1,2-bis(4-isopropoxy-3-methoxyphenyl)ethanone trifluoroacetate

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Technology Process of 2-amino-1,2-bis(4-isopropoxy-3-methoxyphenyl)ethanone trifluoroacetate

There total 6 articles about 2-amino-1,2-bis(4-isopropoxy-3-methoxyphenyl)ethanone trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333109-38-8
tert-butyl (1,2-bis(4-isopropoxy-3-methoxyphenyl)-2-oxoethyl)carbamate

: 76-05-1
trifluoroacetic acid

: 1333109-40-2
2-amino-1,2-bis(4-isopropoxy-3-methoxyphenyl)ethanone trifluoroacetate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.06.056

Reference yield:

: 4-isopropoxy-3-methoxybenzoic acid isopropyl ester

: 1333109-40-2
2-amino-1,2-bis(4-isopropoxy-3-methoxyphenyl)ethanone trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 4 h / Reflux

1.2: pH 3

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

3.1: dmap / acetonitrile / 16 h / 20 °C / Inert atmosphere

4.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide / tetrahydrofuran; hexane / 8 h / -78 °C / Inert atmosphere

5.1: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; acetonitrile;
DOI:10.1016/j.bmc.2011.06.056

Reference yield:

: 1333109-36-6
N-(4-isopropoxy-3-methoxybenzyl)-4-isopropoxy-3-methoxybenzamide

: 1333109-40-2
2-amino-1,2-bis(4-isopropoxy-3-methoxyphenyl)ethanone trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / acetonitrile / 16 h / 20 °C / Inert atmosphere

2: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide / tetrahydrofuran; hexane / 8 h / -78 °C / Inert atmosphere

3: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2011.06.056