1-[2-acetoxy-3-(N-tert-butoxycarbonyl-N-phenylamino)propyl]-4-[4,4-bis(4-fluorophenyl)butyl]piperazine

Base Information

Chemical Name:1-[2-acetoxy-3-(N-tert-butoxycarbonyl-N-phenylamino)propyl]-4-[4,4-bis(4-fluorophenyl)butyl]piperazine
CAS No.:641638-03-1
Molecular Formula:C₃₆H₄₅F₂N₃O₄
Molecular Weight:621.768
Hs Code.:

Synonyms:1-[2-acetoxy-3-(N-tert-butoxycarbonyl-N-phenylamino)propyl]-4-[4,4-bis(4-fluorophenyl)butyl]piperazine

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Chemical Property of 1-[2-acetoxy-3-(N-tert-butoxycarbonyl-N-phenylamino)propyl]-4-[4,4-bis(4-fluorophenyl)butyl]piperazine

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Technology Process of 1-[2-acetoxy-3-(N-tert-butoxycarbonyl-N-phenylamino)propyl]-4-[4,4-bis(4-fluorophenyl)butyl]piperazine

There total 4 articles about 1-[2-acetoxy-3-(N-tert-butoxycarbonyl-N-phenylamino)propyl]-4-[4,4-bis(4-fluorophenyl)butyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 108-24-7
acetic anhydride

: 490576-34-6
1-[4,4-bis(4-fluorophenyl)butyl]-4-[3-(N-tert-butoxycarbonyl-N-phenylamino)-2-hydroxypropyl]piperazine

: 641638-03-1
1-[2-acetoxy-3-(N-tert-butoxycarbonyl-N-phenylamino)propyl]-4-[4,4-bis(4-fluorophenyl)butyl]piperazine

Guidance literature:: With pyridine; at 20 ℃; for 60h;
DOI:10.1016/S0968-0896(03)00428-0

Reference yield:

: 3422-01-3
tert-butyl phenylcarbamate

: 641638-03-1
1-[2-acetoxy-3-(N-tert-butoxycarbonyl-N-phenylamino)propyl]-4-[4,4-bis(4-fluorophenyl)butyl]piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / sodium hydride / dimethylformamide / 20 °C

2: 74 percent / ethanol / 20 °C

3: 89 percent / pyridine / 60 h / 20 °C

With pyridine; sodium hydride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(03)00428-0

Reference yield:

: 5631-35-6
1-[4,4-bis(4-fluorophenyl)butyl]piperazine

: 641638-03-1
1-[2-acetoxy-3-(N-tert-butoxycarbonyl-N-phenylamino)propyl]-4-[4,4-bis(4-fluorophenyl)butyl]piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / ethanol / 20 °C

2: 89 percent / pyridine / 60 h / 20 °C

With pyridine; In ethanol;
DOI:10.1016/S0968-0896(03)00428-0