(1E)-2,3-dihydro-5-[[5-hydroxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-1H-inden-1-one oxime

Base Information

Chemical Name:(1E)-2,3-dihydro-5-[[5-hydroxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-1H-inden-1-one oxime
CAS No.:1264925-70-3
Molecular Formula:C₂₀H₁₈N₄O₂
Molecular Weight:346.389
Hs Code.:

Synonyms:(1E)-2,3-dihydro-5-[[5-hydroxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-1H-inden-1-one oxime

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Chemical Property of (1E)-2,3-dihydro-5-[[5-hydroxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-1H-inden-1-one oxime

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Technology Process of (1E)-2,3-dihydro-5-[[5-hydroxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-1H-inden-1-one oxime

There total 4 articles about (1E)-2,3-dihydro-5-[[5-hydroxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-1H-inden-1-one oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264925-68-9
4-[(2,3-dihydro-1-hydroxy-1H-inden-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

: 1264925-70-3
(1E)-2,3-dihydro-5-[[5-hydroxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-1H-inden-1-one oxime

Guidance literature:: With hydroxylamine hydrochloride; In pyridine; at 20 ℃;

Reference yield:

: 1264926-86-4
5-(benzyloxy)-4-chloro-6-p-tolylpyrimidine

: 1264925-70-3
(1E)-2,3-dihydro-5-[[5-hydroxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-1H-inden-1-one oxime

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16 h / 130 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3: sodium tetrahydroborate; methanol / 20 °C

4: hydroxylamine hydrochloride / pyridine / 20 °C

With methanol; sodium tetrahydroborate; hydroxylamine hydrochloride; hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In pyridine; methanol; toluene;

Reference yield:

: 1264927-06-1
C₂₇H₂₃N₃O₂

: 1264925-70-3
(1E)-2,3-dihydro-5-[[5-hydroxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-1H-inden-1-one oxime

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

2: sodium tetrahydroborate; methanol / 20 °C

3: hydroxylamine hydrochloride / pyridine / 20 °C

With methanol; sodium tetrahydroborate; hydroxylamine hydrochloride; hydrogen; palladium 10% on activated carbon; In pyridine; methanol;