4-[(2,3-dihydro-1-hydroxy-1H-inden-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

Base Information

Chemical Name:4-[(2,3-dihydro-1-hydroxy-1H-inden-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol
CAS No.:1264925-68-9
Molecular Formula:C₂₀H₁₉N₃O₂
Molecular Weight:333.39
Hs Code.:

Synonyms:4-[(2,3-dihydro-1-hydroxy-1H-inden-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

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Chemical Property of 4-[(2,3-dihydro-1-hydroxy-1H-inden-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

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Technology Process of 4-[(2,3-dihydro-1-hydroxy-1H-inden-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

There total 3 articles about 4-[(2,3-dihydro-1-hydroxy-1H-inden-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1264925-66-7
2,3-dihydro-5-[[5-hydroxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-1H-inden-1-one

: 1264925-68-9
4-[(2,3-dihydro-1-hydroxy-1H-inden-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

Guidance literature:: With methanol; sodium tetrahydroborate; at 20 ℃;

Reference yield:

: 1264926-86-4
5-(benzyloxy)-4-chloro-6-p-tolylpyrimidine

: 1264925-68-9
4-[(2,3-dihydro-1-hydroxy-1H-inden-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16 h / 130 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3: sodium tetrahydroborate; methanol / 20 °C

With methanol; sodium tetrahydroborate; hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; toluene;

Reference yield:

: 1264927-06-1
C₂₇H₂₃N₃O₂

: 1264925-68-9
4-[(2,3-dihydro-1-hydroxy-1H-inden-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

2: sodium tetrahydroborate; methanol / 20 °C

With methanol; sodium tetrahydroborate; hydrogen; palladium 10% on activated carbon; In methanol;