(5S,7aR)-(-)-4,7a-dimethyl-2-(toluene-4-sulfonyl)-2,3,5,6,7,7a-hexahydro-1H-isoindole-5-carboxylic acid dimethylamide

Base Information

Chemical Name:(5S,7aR)-(-)-4,7a-dimethyl-2-(toluene-4-sulfonyl)-2,3,5,6,7,7a-hexahydro-1H-isoindole-5-carboxylic acid dimethylamide
CAS No.:1448245-18-8
Molecular Formula:C₂₀H₂₈N₂O₃S
Molecular Weight:376.52
Hs Code.:

Synonyms:(5S,7aR)-(-)-4,7a-dimethyl-2-(toluene-4-sulfonyl)-2,3,5,6,7,7a-hexahydro-1H-isoindole-5-carboxylic acid dimethylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5S,7aR)-(-)-4,7a-dimethyl-2-(toluene-4-sulfonyl)-2,3,5,6,7,7a-hexahydro-1H-isoindole-5-carboxylic acid dimethylamide

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Technology Process of (5S,7aR)-(-)-4,7a-dimethyl-2-(toluene-4-sulfonyl)-2,3,5,6,7,7a-hexahydro-1H-isoindole-5-carboxylic acid dimethylamide

There total 1 articles about (5S,7aR)-(-)-4,7a-dimethyl-2-(toluene-4-sulfonyl)-2,3,5,6,7,7a-hexahydro-1H-isoindole-5-carboxylic acid dimethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2680-03-7,68761-83-1
N,N-Dimethylacrylamide

: 292607-11-5
N-(but-2-ynyl)-4-methyl-N-(2-methylallyl)benzenesulfonamide

: 4-[4,4-dimethyl-1-(toluene-4-sulfonyl)pyrrolidin-3-ylidene]pent-2-enoic acid dimethylamide

: 1448245-18-8
(5S,7aR)-(-)-4,7a-dimethyl-2-(toluene-4-sulfonyl)-2,3,5,6,7,7a-hexahydro-1H-isoindole-5-carboxylic acid dimethylamide

Guidance literature:: With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; (R)-(+)-2,2'-bis(diphenylphosphanyl)-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl; In dichloromethane; at 20 ℃; for 16h; enantioselective reaction; Schlenk technique;
DOI:10.1002/anie.201206122

Reference yield: 55.0%

: 1448245-18-8
(5S,7aR)-(-)-4,7a-dimethyl-2-(toluene-4-sulfonyl)-2,3,5,6,7,7a-hexahydro-1H-isoindole-5-carboxylic acid dimethylamide

: 1448245-47-3
(1aS,2S,4aS,7aS)-(-)-1a,4a-dimethyl-6-(toluene-4-sulfonyl)octahydro-1-oxa-6-azacyclopropa[d]indene-2-carboxylic acid dimethylamide

: 1448245-48-4
(-)-1a,4a-dimethyl-6-(toluene-4-sulfonyl)octahydro-1-oxa-6-azacyclopropa[d]indene-2-carboxylic acid dimethylamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 16h; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.201206122