6-(4-benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine

Base Information

Chemical Name:6-(4-benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine
CAS No.:1452808-98-8
Molecular Formula:C₂₁H₂₆N₆
Molecular Weight:362.478
Hs Code.:

Synonyms:6-(4-benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine

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Chemical Property of 6-(4-benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine

Chemical Property:

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Technology Process of 6-(4-benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine

There total 6 articles about 6-(4-benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₂₄N₂

: 87-42-3
6-chloropurine

: 1452808-98-8
6-(4-benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine

Guidance literature:: With triethylamine; In butan-1-ol; at 100 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.07.021

Reference yield:

: 1452808-96-6
1,4,9-tribenzyl-1,9-diazaspiro[5.5]undecan-2-one

: 1452808-98-8
6-(4-benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran; toluene / 3 h / 50 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol / 96 h / 50 °C / 760.05 Torr

3: triethylamine / butan-1-ol / 16 h / 100 °C / Inert atmosphere

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; toluene; butan-1-ol;
DOI:10.1016/j.bmc.2013.07.021

Reference yield:

: N-(4-allyl-1-benzylpiperidin-4-yl)-N-benzylacrylamide

: 1452808-98-8
6-(4-benzyl-1,9-diazaspiro[5.5]undecan-9-yl)-9H-purine

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium(IV) isopropylate / dichloromethane / 1 h / Inert atmosphere; Reflux

1.2: 3 h / Reflux; Inert atmosphere

2.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 0.5 h / -40 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran; toluene / 3 h / 50 °C / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / methanol / 96 h / 50 °C / 760.05 Torr

5.1: triethylamine / butan-1-ol / 16 h / 100 °C / Inert atmosphere

With titanium(IV) isopropylate; lithium aluminium tetrahydride; copper(I) bromide dimethylsulfide complex; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; butan-1-ol;
DOI:10.1016/j.bmc.2013.07.021