1,4,9-tribenzyl-1,9-diazaspiro[5.5]undecane

Base Information

Chemical Name:1,4,9-tribenzyl-1,9-diazaspiro[5.5]undecane
CAS No.:1452809-28-7
Molecular Formula:C₃₀H₃₆N₂
Molecular Weight:424.629
Hs Code.:

Synonyms:1,4,9-tribenzyl-1,9-diazaspiro[5.5]undecane

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Chemical Property of 1,4,9-tribenzyl-1,9-diazaspiro[5.5]undecane

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Technology Process of 1,4,9-tribenzyl-1,9-diazaspiro[5.5]undecane

There total 4 articles about 1,4,9-tribenzyl-1,9-diazaspiro[5.5]undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1452808-96-6
1,4,9-tribenzyl-1,9-diazaspiro[5.5]undecan-2-one

: 1452809-28-7
1,4,9-tribenzyl-1,9-diazaspiro[5.5]undecane

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; toluene; at 50 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.07.021

Reference yield:

: N-(4-allyl-1-benzylpiperidin-4-yl)-N-benzylacrylamide

: 1452809-28-7
1,4,9-tribenzyl-1,9-diazaspiro[5.5]undecane

Guidance literature:: Multi-step reaction with 3 steps

1.1: titanium(IV) isopropylate / dichloromethane / 1 h / Inert atmosphere; Reflux

1.2: 3 h / Reflux; Inert atmosphere

2.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 0.5 h / -40 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran; toluene / 3 h / 50 °C / Inert atmosphere

With titanium(IV) isopropylate; lithium aluminium tetrahydride; copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1016/j.bmc.2013.07.021

Reference yield:

: 1452808-94-4
1,9-dibenzyl-1,9-diazaspiro[5.5]undec-3-en-2-one

: 1452809-28-7
1,4,9-tribenzyl-1,9-diazaspiro[5.5]undecane

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 0.5 h / -40 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran; toluene / 3 h / 50 °C / Inert atmosphere

With lithium aluminium tetrahydride; copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1016/j.bmc.2013.07.021