ethyl 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoate

Base Information

Chemical Name:ethyl 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoate
CAS No.:1198181-48-4
Molecular Formula:C₁₆H₁₈F₄O₃
Molecular Weight:334.311
Hs Code.:

Synonyms:ethyl 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoate

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Chemical Property of ethyl 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoate

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Technology Process of ethyl 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoate

There total 2 articles about ethyl 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1899-24-7
5-bromo-2-furancarboxaldehyde

: 1198181-48-4
ethyl 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ISOPROPYLAMIDE / 16 h / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 26 h / 20 °C

With hydrogen; sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 50527-72-5
3-(5-bromo-furan-2-yl)-acrylic acid ethyl ester

: 1198181-48-4
ethyl 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ISOPROPYLAMIDE / 16 h / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 26 h / 20 °C

With hydrogen; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; ISOPROPYLAMIDE;

Reference yield: 79.0%

: 1198181-48-4
ethyl 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoate

: 1198180-58-3
3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoic acid

Guidance literature:: ethyl 3-{5-[2-fluoro-3-(trifluoromethyl)phenyl]tetrahydrofuran-2-yl}propanoate; With water; lithium hydroxide; In ethanol; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=2;