2-(4-bromo-3,5-dimethylphenoxy)-N-[3-(4-methylpiperazin-1-yl)propyl]acetamide dihydrochloride

Base Information

• Chemical Name: 2-(4-bromo-3,5-dimethylphenoxy)-N-[3-(4-methylpiperazin-1-yl)propyl]acetamide dihydrochloride
• CAS No.: 86746-06-7
• Molecular Formula: C₁₈H₂₈BrN₃O₂*2ClH
• Molecular Weight: 471.265
• Mol file: 86746-06-7.mol

Synonyms:

Chemical Property of 2-(4-bromo-3,5-dimethylphenoxy)-N-[3-(4-methylpiperazin-1-yl)propyl]acetamide dihydrochloride

Chemical Property:

• Vapor Pressure: 2.95E-12mmHg at 25°C
• Boiling Point: 552.6°C at 760 mmHg
• Flash Point: 288°C

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-bromo-3,5-dimethylphenoxy)-N-[3-(4-methylpiperazin-1-yl)propyl]acetamide dihydrochloride

There total 3 articles about 2-(4-bromo-3,5-dimethylphenoxy)-N-[3-(4-methylpiperazin-1-yl)propyl]acetamide dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3-(N-methylpiperazino)propylamine (4572-03-6) + (4-bromo-3,5-dimethylphenoxy)acetic acid methyl ester (86745-93-9) → 2-(4-Bromo-3,5-dimethyl-phenoxy)-N-[3-(4-methyl-piperazin-1-yl)-propyl]-acetamide; hydrochloride (86746-06-7)

Guidance literature:

With hydrogenchloride; 1.) ethanol, reflux 20 h, 2.) ether;

DOI:10.1135/cccc19831089

Reference yield:

4-bromo-3,5-dimethylphenol (7463-51-6) → 2-(4-Bromo-3,5-dimethyl-phenoxy)-N-[3-(4-methyl-piperazin-1-yl)-propyl]-acetamide; hydrochloride (86746-06-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / NaOH / H₂O / 1.) 90 deg C, 1 h, 2.) 4 h.

2: 58 percent / methanol / 10 h / Heating

3: 74 percent / HCl / 1.) ethanol, reflux 20 h, 2.) ether

With hydrogenchloride; sodium hydroxide; In methanol; water;

DOI:10.1135/cccc19831089

Reference yield:

sodium 4-bromo-3,5-dimethylphenoxyacetate (86745-92-8) → 2-(4-Bromo-3,5-dimethyl-phenoxy)-N-[3-(4-methyl-piperazin-1-yl)-propyl]-acetamide; hydrochloride (86746-06-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / methanol / 10 h / Heating

2: 74 percent / HCl / 1.) ethanol, reflux 20 h, 2.) ether

With hydrogenchloride; In methanol;

DOI:10.1135/cccc19831089

upstream raw materials:

3-(N-methylpiperazino)propylamine

(4-bromo-3,5-dimethylphenoxy)acetic acid methyl ester

4-bromo-3,5-dimethylphenol

sodium 4-bromo-3,5-dimethylphenoxyacetate