5-(3-methoxyphenyl)-2-phenyl-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole

Base Information

• Chemical Name: 5-(3-methoxyphenyl)-2-phenyl-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole
• CAS No.: 1621514-66-6
• Molecular Formula: C₂₄H₁₆F₃N₃OS
• Molecular Weight: 451.472

Synonyms:5-(3-methoxyphenyl)-2-phenyl-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole

Chemical Property of 5-(3-methoxyphenyl)-2-phenyl-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole

Chemical Property:

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Technology Process of 5-(3-methoxyphenyl)-2-phenyl-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole

There total 3 articles about 5-(3-methoxyphenyl)-2-phenyl-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-methoxyphenyl bromide (2398-37-0) + 2-phenyl-6-[4-(trifluoromethyl)phenyl]thiazolo[3,2-b][1,2,4]triazole (1621514-58-6) → 5-(3-methoxyphenyl)-2-phenyl-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole (1621514-66-6)

Guidance literature:

With palladium diacetate; caesium carbonate; tricyclohexylphosphine; In 1,4-dioxane; at 130 ℃; for 15h; Sealed tube; Inert atmosphere;

DOI:10.1002/ejoc.201402193

Reference yield:

5-phenyl-1H-1,2,4-triazole-3-thiol (3414-94-6) → 5-(3-methoxyphenyl)-2-phenyl-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole (1621514-66-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol; water / 3 h / Reflux

1.2: 0 - 20 °C

2.1: caesium carbonate; palladium diacetate; tricyclohexylphosphine / 1,4-dioxane / 15 h / 130 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; palladium diacetate; caesium carbonate; tricyclohexylphosphine; In 1,4-dioxane; ethanol; water;

DOI:10.1002/ejoc.201402193

Reference yield:

2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone (383-53-9) → 5-(3-methoxyphenyl)-2-phenyl-6-[4-(trifluoromethyl)phenyl]thiazolo-[3,2-b][1,2,4]triazole (1621514-66-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / ethanol; water / 3 h / Reflux

1.2: 0 - 20 °C

2.1: caesium carbonate; palladium diacetate; tricyclohexylphosphine / 1,4-dioxane / 15 h / 130 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; palladium diacetate; caesium carbonate; tricyclohexylphosphine; In 1,4-dioxane; ethanol; water;

DOI:10.1002/ejoc.201402193

upstream raw materials:

3-methoxyphenyl bromide

2-phenyl-6-[4-(trifluoromethyl)phenyl]thiazolo[3,2-b][1,2,4]triazole

5-phenyl-1H-1,2,4-triazole-3-thiol

2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

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