(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-{4-[2,5-dichloro-4-(2-hydroxy-ethoxy)-phenoxy]-pyridin-3-yl}-methanone

Base Information

Chemical Name:(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-{4-[2,5-dichloro-4-(2-hydroxy-ethoxy)-phenoxy]-pyridin-3-yl}-methanone
CAS No.:1315469-23-8
Molecular Formula:C₂₅H₂₃Cl₂N₃O₄
Molecular Weight:500.381
Hs Code.:

Synonyms:(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-{4-[2,5-dichloro-4-(2-hydroxy-ethoxy)-phenoxy]-pyridin-3-yl}-methanone

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Chemical Property of (4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-{4-[2,5-dichloro-4-(2-hydroxy-ethoxy)-phenoxy]-pyridin-3-yl}-methanone

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Technology Process of (4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-{4-[2,5-dichloro-4-(2-hydroxy-ethoxy)-phenoxy]-pyridin-3-yl}-methanone

There total 11 articles about (4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-{4-[2,5-dichloro-4-(2-hydroxy-ethoxy)-phenoxy]-pyridin-3-yl}-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1315469-18-1
(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxy-phenoxy)-pyridin-3-yl]-methanone

: 540-51-2
2-bromoethanol

: 1315469-23-8
(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-{4-[2,5-dichloro-4-(2-hydroxy-ethoxy)-phenoxy]-pyridin-3-yl}-methanone

Guidance literature:: (4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-[4-(2,5-dichloro-4-hydroxy-phenoxy)-pyridin-3-yl]-methanone; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.25h;

2-bromoethanol; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 75h;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1315469-23-8
(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-{4-[2,5-dichloro-4-(2-hydroxy-ethoxy)-phenoxy]-pyridin-3-yl}-methanone

Guidance literature:: Multi-step reaction with 8 steps

1.1: 19 h / 20 - 30 °C

2.1: triethylamine / dichloromethane / 72 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 900.09 Torr

4.1: triphenylphosphine / N,N-dimethyl-formamide / 4 h / 135 °C

5.1: borane-THF / tetrahydrofuran / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 17 h / 20 °C

7.1: n-butyllithium; Triisopropyl borate / hexane; tetrahydrofuran / 1.55 h / -75 °C / Dry ice bath

7.2: 21 h / 0 - 20 °C

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

8.2: 75 h / 20 °C

With n-butyllithium; borane-THF; Triisopropyl borate; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1940-42-7,79151-08-9
4-bromo-2,5-dichlorophenol

: 1315469-23-8
(4-cyclopropyl-3,4-dihydro-2H-quinoxalin-1-yl)-{4-[2,5-dichloro-4-(2-hydroxy-ethoxy)-phenoxy]-pyridin-3-yl}-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / tetrakis(actonitrile)copper(I) hexafluorophosphate / o-xylene / 16 h / 120 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 17 h / 20 °C

3.1: n-butyllithium; Triisopropyl borate / hexane; tetrahydrofuran / 1.55 h / -75 °C / Dry ice bath

3.2: 21 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

4.2: 75 h / 20 °C

With n-butyllithium; Triisopropyl borate; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(actonitrile)copper(I) hexafluorophosphate; In tetrahydrofuran; hexane; o-xylene; N,N-dimethyl-formamide; mineral oil;