ethyl (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate

Base Information

Chemical Name:ethyl (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate
CAS No.:945635-19-8
Molecular Formula:C₂₀H₂₉NO₇S
Molecular Weight:427.519
Hs Code.:

Synonyms:ethyl (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate

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Chemical Property of ethyl (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate

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Technology Process of ethyl (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate

There total 2 articles about ethyl (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 945635-17-6
ethyl (S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylate

: 112-35-6,95507-80-5
triethylene glucol monomethyl ether

: 945635-19-8
ethyl (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 8h;
DOI:10.1021/jm070214s

Reference yield:

: 847355-88-8
(S)-2-(2,3-dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylic acid

: 945635-19-8
ethyl (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / N,N-diisopropylethylamine / dimethylformamide / 48 h / 20 °C

2: 25 percent / diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 8 h / 20 °C

With di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1021/jm070214s

Reference yield:

: 945635-19-8
ethyl (S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate

: C₁₈H₂₄NO₇S^(1-)*Na⁽¹⁺⁾

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; sodium hydroxide / 6 h / 0 - 20 °C

1.2: pH 2

2.1: H₂₀

With methanol; sodium hydroxide; In H₂₀;