N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-fluorophenyl)acrylamide trifluoroacetate

Base Information

Chemical Name:N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-fluorophenyl)acrylamide trifluoroacetate
CAS No.:1431959-19-1
Molecular Formula:C₂HF₃O₂*C₁₉H₁₈FN₅OS
Molecular Weight:497.473
Hs Code.:

Synonyms:N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-fluorophenyl)acrylamide trifluoroacetate

Suppliers and Price of N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-fluorophenyl)acrylamide trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-fluorophenyl)acrylamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-fluorophenyl)acrylamide trifluoroacetate

There total 3 articles about N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-fluorophenyl)acrylamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431960-49-4
C₁₆H₁₆FN₅S

: 814-68-6,25189-84-8
acryloyl chloride

: 76-05-1
trifluoroacetic acid

: 1431959-19-1
N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-fluorophenyl)acrylamide trifluoroacetate

Guidance literature:: C₁₆H₁₆FN₅S; acryloyl chloride; With triethylamine; In tetrahydrofuran; at -70 - 20 ℃; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 888498-07-5
(1H-pyrrolo[2,3-b]pyridin-4-yl)methanamine

: 1431959-19-1
N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-fluorophenyl)acrylamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; dmap / methanol / 0.5 h / 20 °C / Cooling with ice

1.2: 1.58 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 12 h / 20 °C

3.1: triethylamine / tetrahydrofuran / -70 - 20 °C / Inert atmosphere

With dmap; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 53312-81-5
3-cyano-4-fluoroaniline

: 1431959-19-1
N-(3-((3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)methyl)-4-fluorophenyl)acrylamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; cobalt(II) chloride hexahydrate / methanol / 0 - 20 °C

2: triethylamine / dichloromethane / 12 h / 20 °C

3: triethylamine / tetrahydrofuran / -70 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; cobalt(II) chloride hexahydrate; triethylamine; In tetrahydrofuran; methanol; dichloromethane;