2,3,4-Trimethoxyphenylethylamine

Base Information

• Chemical Name: 2,3,4-Trimethoxyphenylethylamine
• CAS No.: 4722-08-1
• Molecular Formula: C₁₁H₁₇NO₃
• Molecular Weight: 211.261
• DSSTox Substance ID: DTXSID70963774
• Mol file: 4722-08-1.mol

Synonyms:2,3,4-trimethoxyphenylethylamine;4722-08-1;2-(3,4-dimethoxyphenyl)-2-methoxyethanamine;beta,3,4-Trimethoxyphenethylamine;Phenethylamine, beta,3,4-trimethoxy-;SCHEMBL6380574;DTXSID70963774;CFEHWNSMGUKJEU-UHFFFAOYSA-N;AKOS005218261;2-(3,4-Dimethoxy-phenyl)-2-methoxy-ethylamine;EN300-7549974;2-(3,4-Dimethoxyphenyl)-2-methoxyethan-1-amine

Chemical Property of 2,3,4-Trimethoxyphenylethylamine

Chemical Property:

• Vapor Pressure: 0.00056mmHg at 25°C
• Boiling Point: 311.5°C at 760 mmHg
• Flash Point: 145.4°C
• Density: 1.069g/cm³
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 211.12084340
• Heavy Atom Count: 15
• Complexity: 177

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C(CN)OC)OC

Technology Process of 2,3,4-Trimethoxyphenylethylamine

There total 7 articles about 2,3,4-Trimethoxyphenylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(dimethoxy-3,4 phenyl)-2 methoxy-2 nitro-1 ethane (57542-90-2) → 3,4-dimethoxy-β-methoxybenzeneethanamine (4722-08-1,783256-00-8)

Guidance literature:

With hydrogen; nickel; In ethanol; under 2844.3 Torr;

DOI:10.1021/jm00356a011

Reference yield:

1,2-dimethoxy-4-(2-nitro-vinyl)-benzene (4230-93-7) → 3,4-dimethoxy-β-methoxybenzeneethanamine (4722-08-1,783256-00-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 44 percent / methanol

2: 78 percent / H₂ / Raney Ni / ethanol / 2844.3 Torr

With hydrogen; nickel; In methanol; ethanol;

DOI:10.1021/jm00356a011

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → 3,4-dimethoxy-β-methoxybenzeneethanamine (4722-08-1,783256-00-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / ammonium acetate / benzene / 6 h / Heating

2: 44 percent / methanol

3: 78 percent / H₂ / Raney Ni / ethanol / 2844.3 Torr

With ammonium acetate; hydrogen; nickel; In methanol; ethanol; benzene;

DOI:10.1021/jm00356a011

upstream raw materials:

(dimethoxy-3,4 phenyl)-2 methoxy-2 nitro-1 ethane

4-(2-bromo-1-methoxy-ethyl)-1,2-dimethoxy-benzene

acetic acid

1,2-dimethoxy-4-(2-nitro-vinyl)-benzene

Downstream raw materials:

(2,3-dimethoxy-phenyl)-acetic acid-(3,4,β-trimethoxy-phenethylamide)

N-(3'-Benzyloxy-4'-methoxyphenylacetyl)-β-methoxy-β-(3,4-dimethoxyphenyl)-ethylamin

N-[2-(3,4-dimethoxyphenyl)-2-methoxyethyl]benzamide

phenyl-acetic acid-(3,4,β-trimethoxy-phenethylamide)