4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis(2'-chloroethyl)aniline

Base Information

Chemical Name:4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis(2'-chloroethyl)aniline
CAS No.:528836-68-2
Molecular Formula:C₁₉H₂₂Cl₂N₂O₂
Molecular Weight:381.302
Hs Code.:

Synonyms:4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis(2'-chloroethyl)aniline

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Chemical Property of 4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis(2'-chloroethyl)aniline

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Technology Process of 4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis(2'-chloroethyl)aniline

There total 8 articles about 4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis(2'-chloroethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.5%

: 528836-53-5
4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis(2'-mesyloxyethyl)aniline

: 528836-68-2
4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis(2'-chloroethyl)aniline

Guidance literature:: With lithium chloride; In N,N-dimethyl acetamide; at 20 ℃;
DOI:10.1021/jm020462i

Reference yield:

: 18226-17-0
N,N-bis(2-hydroxyethyl)-4-nitroaniline

: 528836-68-2
4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis(2'-chloroethyl)aniline

Guidance literature:: Multi-step reaction with 7 steps

1.1: 89 percent / imidazole / dimethylformamide / 20 h / 20 °C

2.1: 95 percent / H₂ / Pd/C / tetrahydrofuran / 6 h

3.1: 95 percent / tetrahydrofuran / 16 h / 20 °C

4.1: NaH / tetrahydrofuran / 0.67 h / 20 °C

4.2: 100 percent / tetrahydrofuran / 12 h / 20 °C

5.1: 88 percent / triethylamine trihydrofluoride / tetrahydrofuran / 20 °C

6.1: 100 percent / 4-(N,N-dimethyl)aminopyridine; Et₃N / CH₂Cl₂ / 20 °C

7.1: 62.5 percent / LiCl / N,N-dimethyl-acetamide / 20 °C

With 1H-imidazole; dmap; triethylamine trihydrofluoride; hydrogen; sodium hydride; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm020462i

Reference yield:

: 304015-61-0
N,N-bis(2-{[tert-butyldimethylsilyl]oxy}ethyl)-4-nitroaniline

: 528836-68-2
4-(N'-benzyloxycarbonyl-N'-methyl)amino-N,N-bis(2'-chloroethyl)aniline

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / H₂ / Pd/C / tetrahydrofuran / 6 h

2.1: 95 percent / tetrahydrofuran / 16 h / 20 °C

3.1: NaH / tetrahydrofuran / 0.67 h / 20 °C

3.2: 100 percent / tetrahydrofuran / 12 h / 20 °C

4.1: 88 percent / triethylamine trihydrofluoride / tetrahydrofuran / 20 °C

5.1: 100 percent / 4-(N,N-dimethyl)aminopyridine; Et₃N / CH₂Cl₂ / 20 °C

6.1: 62.5 percent / LiCl / N,N-dimethyl-acetamide / 20 °C

With dmap; triethylamine trihydrofluoride; hydrogen; sodium hydride; triethylamine; lithium chloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm020462i