trans/trans-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

Base Information

Chemical Name:trans/trans-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester
CAS No.:1417611-63-2
Molecular Formula:C₂₄H₃₃NO₆
Molecular Weight:431.529
Hs Code.:

Synonyms:trans/trans-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

Suppliers and Price of trans/trans-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans/trans-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans/trans-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

There total 2 articles about trans/trans-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417611-61-0
3-(3,4,5-trimethoxyphenyl)propiolic acid 4-oxocyclohexyl ester

: 27489-62-9
trans-4-hydroxycyclohexylamine

: 1417611-62-1
cis/trans-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

: 1417611-63-2
trans/trans-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

Guidance literature:: 3-(3,4,5-trimethoxyphenyl)propiolic acid 4-oxocyclohexyl ester; trans-4-hydroxycyclohexylamine; With titanium(IV) isopropylate; sodium cyanoborohydride; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In ethanol; for 20h; Overall yield = 40 %; Overall yield = 370 mg;
DOI:10.1016/j.bmc.2012.11.019

Reference yield:

: 13482-22-9
4-hydroxycyclohexanone

: 1417611-63-2
trans/trans-3-(3,4,5-trimethoxyphenyl)propiolic acid 4-(4-hydroxycyclohexylamino)cyclohexyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 49 h / 0 - 20 °C

2.1: titanium(IV) isopropylate; sodium cyanoborohydride / 3 h / 20 °C

2.2: 20 h

With titanium(IV) isopropylate; dmap; sodium cyanoborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.bmc.2012.11.019