4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid

Base Information

Chemical Name:4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid
CAS No.:1229419-12-8
Molecular Formula:C₂₈H₂₃F₃N₄O₄
Molecular Weight:536.51
Hs Code.:

Synonyms:4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid

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Chemical Property of 4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid

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Technology Process of 4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid

There total 2 articles about 4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 403-45-2
6-fluoronicotinic acid

: 1085841-74-2
2-phenyl-N-[4-piperidin-4-ylphenyl]-5-trifluoromethyl-1,3-oxazole-4-carboxamide

: 1229419-12-8
4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid

Guidance literature:: 6-fluoronicotinic acid; 2-phenyl-N-[4-piperidin-4-ylphenyl]-5-trifluoromethyl-1,3-oxazole-4-carboxamide; With potassium carbonate; In dimethyl sulfoxide; at 135 ℃; for 0.583333h; Microwave irradiation;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

: 1085843-34-0
4-{4-[(2-phenyl-5-trifluoromethyloxazole-4-carbonyl)amino]phenyl}piperidine-1-carboxylic acid tert-butyl ester

: 1229419-12-8
4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenyl}-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

1.2: pH > 10

2.1: potassium carbonate / dimethyl sulfoxide / 0.58 h / 135 °C / Microwave irradiation

With potassium carbonate; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;