403-45-2

Basic information

• Product Name: 6-Fluoronicotinic acid
• Synonyms: 6-Fluoronicotinc Acid;2-Fluoropyridine-5-carboxylic acid, 6-Fluoropyridine-3-carboxylic acid, 5-Carboxy-2-fluoropyridine;2-FLUOROPYRIDINE-5-CARBOXYLIC ACID;2-FLUORO-5-PYRIDINE CARBOXYLIC ACID;2-Fluoro-5-pyridine carboxylic acid(6-Fluoronicotinic acid);6-FLUORONICOTINIC ACID;6-FLUOROPYRIDINE-3-CARBOXYLIC ACID;6-FLUOROPYRIDINE-3-FORMIC ACID
• CAS NO: 403-45-2
• Molecular Formula: C₆H₄FNO₂
• Molecular Weight: 141.1
• Product Categories: C6;Chemical Synthesis;Fluorinated Building Blocks;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;Pyridine;Pyridine series;Pyridines;Building Blocks;Carboxy;Boronic Acid;Picolinic acid series
• Mol File: 403-45-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: 144-148 °C(lit.)
• Boiling Point: 309.4 °C at 760 mmHg
• Flash Point: 140.9 °C
• Appearance: /
• Density: 1.419 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.41±0.10(Predicted)
• CAS DataBase Reference: 6-Fluoronicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoronicotinic acid(403-45-2)
• EPA Substance Registry System: 6-Fluoronicotinic acid(403-45-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 403-45-2(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

It is used as a pharmaceutical intermediate.

Upstream product

• 2369-19-9 2-fluoro-5-methylpyridine 
• 59-67-6 nicotinic acid 
• 171197-80-1 2-fluoro-5-iodopyridine 
• 1603-41-4 (5-methyl-pyridin-2-yl)amine 

Downstream Products

• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 369-50-6 6-fluoronicotinamide 
• 676560-01-3 6-fluoronicotinic acid tert-butyl ester 
• 362028-72-6 6-[Ethyl-(8-ethyl-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-amino]-nicotinic Acid 
• 1427-06-1 methyl 6-fluoropyridine-3-carboxylate 
• 1005787-45-0 N-[6-(3-{[3-(1-cyanocyclopropyl)benzoyl]amino}phenoxy)imidazo[1,2-b]pyridazin-2-yl]-6-fluoronicotinamide 
• 1323276-55-6 (S)-N-(2-(3-(2-cyanophenoxy)-2-hydroxypropylamino)ethyl)-6-fluoronicotinamide 
• 1380111-65-8 C₂₆H₂₂FN₃O₄ 
• 1383798-69-3 (+/-)-3-(6-(3-methyl-1-(4-(6-methylpyridin-3-yl)phenyl)butylamino)nicotinamido)propanoic acid 
• 1383801-02-2 (S)-N-({6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]pyridin-3-yl}carbonyl)-β-alanine 
• 1383802-45-6 3-[(6-{(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamino}-pyridine-3-carbonyl)-amino]-propionic acid 
• 1383801-17-9 (S)-6-[(3-methyl-1-{4-[5-(trifluoromethyl)pyridin-2-yl]phenyl}butyl)amino]nicotinic acid 
• 1383801-45-3 (+/-)-6-[(cyclohexyl{2-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}methyl)amino]nicotinic acid 
• 1383802-61-6 3-[(6-{(S)-3-methyl-1-[2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-butylamino}-pyridine-3-carbonyl)-amino]-propionic acid ethyl ester 

Relevant articles and documents

Preparation method of 2-fluoro-5-formyl chloropyridine

The invention relates to a preparation method of 2-fluoro-5-formyl chloropyridine, and belongs to the technical field of organic chemistry. The method comprises the following steps: 1) taking 2-fluoro-5-methylpyridine as a raw material, and reacting in the presence of potassium permanganate or sodium permanganate to obtain 2-fluoro-5-formic acid pyridine; and 2) carrying out reflux reaction on the2-fluoro-5-formic acid pyridine and thionyl chloride or oxalyl chloride in a chlorinated solvent, after the reaction is finished, carrying out reduced pressure distillation on the solvent, adding analkane solvent, freezing, filtering to obtain a 2-fluoro-5-formyl chloropyridine solution, and carrying out reduced pressure distillation to obtain the 2-fluoro-5-formyl chloropyridine. According to the invention, the method has the advantages that the conversion rate is high, the purity of the obtained product reaches 99.0% or above, the single impurity content is smaller than 0.5%, the production cost is low, and the method is suitable for industrial production.

Nickel-catalyzed carboxylation of aryl iodides with lithium formate through catalytic CO recycling

A protocol for the Ni-catalyzed carboxylation of aryl iodides with formate has been developed with good functional group compatibility for the synthesis of a variety of aromatic carboxylic acids under mild conditions. The reaction tolerates other functionalities for cross-coupling, such as aryl bromide, aryl chloride, aryl tosylate, and aryl pinacol boronate. The reaction proceeds through a carbonylation process with in situ generated carbon monoxide in the presence of a catalytic amount of acetic anhydride and lithium formate, avoiding the use of gaseous CO. The strategy of CO recycling in catalytic amounts is critical for the success of the reaction.

Rapid and efficient synthesis of [18F]fluoronicotinamides, [18F]fluoroisonicotinamides and [18F]fluorobenzamides as potential pet radiopharmaceuticals for melanoma imaging

In an attempt to simplify nucleophilic radiofluorination reactions to be amenable for automation, a series of [18F]fluoronicotinamides, [ 18F]fluoroisonicotinamides and [18F]fluorobenzamides were synthesized using one-step