rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

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Chemical Name:rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide
CAS No.:1397683-08-7
Molecular Formula:C₂₀H₁₇N₇O
Molecular Weight:371.401
Hs Code.:

Synonyms:rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

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Chemical Property of rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

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Technology Process of rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

There total 13 articles about rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1397683-46-3
rac-6-(3-amino-phenyl)-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine

: 53234-55-2
5-cyano-pyridine-2-carboxylic acid

: 1397683-08-7
rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

Guidance literature:: 5-cyano-pyridine-2-carboxylic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 20 ℃; for 0.0833333h;

rac-6-(3-amino-phenyl)-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-4-ylamine; In methanol; at 0 - 20 ℃; for 4h;

With sodium carbonate; In methanol; water;

Reference yield: 26.0%

: 1397683-44-1
6-(3-aminophenyl)-6-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine

: 53234-55-2
5-cyano-pyridine-2-carboxylic acid

: 1397683-08-7
rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

Guidance literature:: 5-cyano-pyridine-2-carboxylic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 20 ℃; for 0.0833333h;

6-(3-aminophenyl)-6-methyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4-amine; In methanol; at 0 - 20 ℃; for 4h;
DOI:10.1021/acsmedchemlett.9b00181

Reference yield:

: 1397683-43-0
3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-thione

: 1397683-08-7
rac-5-cyano-pyridine-2-carboxylic acid[3-(4-amino-6-methyl-6,7-dihydro-pyrazolo[1,5-a]pyrazin-6-yl)-phenyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / water; methanol / 6 h / 100 °C / Sealed tube

2.1: zinc / ethanol; acetic acid / 24 °C / Reflux

3.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 0.08 h / 20 °C

3.2: 4 h / 0 - 20 °C

With ammonia; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; zinc; In methanol; ethanol; water; acetic acid;