3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-thione

Base Information

Chemical Name:3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-thione
CAS No.:1397683-43-0
Molecular Formula:C₁₃H₁₁BrN₄O₂S
Molecular Weight:367.226
Hs Code.:

Synonyms:3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-thione

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Chemical Property of 3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-thione

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Technology Process of 3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-thione

There total 9 articles about 3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1397683-40-7
3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one

: 1397683-43-0
3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-thione

Guidance literature:: With pyridine; tetraphosphorus decasulfide; at 110 ℃; for 24h;
DOI:10.1021/acsmedchemlett.9b00181

Reference yield: 87.0%

: 1397683-43-0
3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-thione

Guidance literature:

Reference yield:

: 1397683-33-8
tert-butyl 4-methyl-4-(3-nitrophenyl)-1,2,3-oxathiazolidine-3-carboxylate-2,2-dioxide

: 1397683-43-0
3-bromo-6-methyl-6-(3-nitrophenyl)-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-thione

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 2 h / 130 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; cyclohexane; ethylbenzene / 1 h / -78 °C

2.2: 1 h / -78 - -50 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: potassium acetate / ethanol / 4 h / Reflux

5.1: tetraphosphorus decasulfide; pyridine / 24 h / 110 °C

With pyridine; tetraphosphorus decasulfide; potassium acetate; sodium carbonate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; cyclohexane; ethylbenzene; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.9b00181