2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid {1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)amide hydrochloride

Base Information

Chemical Name:2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid {1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)amide hydrochloride
CAS No.:1376608-15-9
Molecular Formula:C₂₆H₃₁F₃N₈O₂*ClH
Molecular Weight:581.041
Hs Code.:

2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid {1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)amide hydrochloride

Synonyms:2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid {1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)amide hydrochloride

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Chemical Property of 2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid {1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)amide hydrochloride

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Technology Process of 2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid {1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)amide hydrochloride

There total 13 articles about 2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid {1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)amide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376609-97-0
{(3R,4S)-4-(2,5-difluorophenyl)-1-[5-({1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)carbamoyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester

: 1376608-15-9
2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid {1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)amide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; at 0 - 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 951127-26-7
1-(2,5-difluorophenyl)-2-nitroethanol

: 1376608-15-9
2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid {1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)amide hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1.1: dmap; acetic anhydride / 18 h / 0 - 20 °C / Inert atmosphere

2.1: dichloromethane / Inert atmosphere

2.2: -10 - 30 °C

3.1: hydrogen / 18 h / 20 °C / 37503.8 Torr / Autoclave

4.1: triethylamine / tetrahydrofuran / 18 h / 0 - 20 °C

5.1: 2-Methylpentane; diethylamine; isopropyl alcohol

6.1: palladium 10% on activated carbon; hydrogen / toluene / 78 h / 20 - 60 °C / 37503.8 Torr / Autoclave

7.1: triethylamine / 1,2-dichloro-ethane / 16 h / 20 °C

8.1: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C

9.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / dichloromethane; ethyl acetate / 3 h / 20 °C / Inert atmosphere

10.1: hydrogenchloride / methanol; diethyl ether / 18 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; dmap; palladium 10% on activated carbon; water; hydrogen; acetic anhydride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; 2-Methylpentane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; diethylamine; isopropyl alcohol; toluene;

Reference yield:

: 1245079-22-4
[(3R,4S)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1376608-15-9
2-[(3R,4S)-3-amino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid {1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)amide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / 1,2-dichloro-ethane / 16 h / 20 °C

2: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C

3: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / dichloromethane; ethyl acetate / 3 h / 20 °C / Inert atmosphere

4: hydrogenchloride / methanol; diethyl ether / 18 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; water; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;