{(3R,4S)-4-(2,5-difluorophenyl)-1-[5-({1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)carbamoyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester

Base Information

Chemical Name:{(3R,4S)-4-(2,5-difluorophenyl)-1-[5-({1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)carbamoyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester
CAS No.:1376609-97-0
Molecular Formula:C₃₁H₃₉F₃N₈O₄
Molecular Weight:644.697
Hs Code.:

{(3R,4S)-4-(2,5-difluorophenyl)-1-[5-({1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)carbamoyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester

Synonyms:{(3R,4S)-4-(2,5-difluorophenyl)-1-[5-({1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)carbamoyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester

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Chemical Property of {(3R,4S)-4-(2,5-difluorophenyl)-1-[5-({1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)carbamoyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester

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Technology Process of {(3R,4S)-4-(2,5-difluorophenyl)-1-[5-({1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)carbamoyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester

There total 13 articles about {(3R,4S)-4-(2,5-difluorophenyl)-1-[5-({1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)carbamoyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376609-60-7
[1-(3-(1-fluoro-1-methylethyl)-[1,2,4]oxadiazol-5-yl)piperidin-4-yl](methyl)amine

: 1376609-82-3
2-[(3R,4S)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrimidine-5-carboxylic acid

: 1376609-97-0
{(3R,4S)-4-(2,5-difluorophenyl)-1-[5-({1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)carbamoyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 2646-90-4
2,5-difluorobenzaldehyde

: 1376609-97-0
{(3R,4S)-4-(2,5-difluorophenyl)-1-[5-({1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)carbamoyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide / water; methanol / 0.67 h / 4 - 6 °C

1.2: Cooling with ice

2.1: dmap / 18 h / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / -5 - 30 °C

4.1: hydrogen / RaNi / industrial methylated spritis / 18 h / 20 °C / 37503.8 Torr / Autoclave

5.1: di-tert-butyl dicarbonate / tetrahydrofuran / 18 h / 0 - 20 °C

6.1: isopropyl alcohol; diethyl ether; 2-Methylpentane / Resolution of racemate; Autoclave

7.1: hydrogen / palladium 10% on activated carbon / toluene; industrial methylated spirits / 78 h / 20 - 60 °C

8.1: triethylamine / 1,2-dichloro-ethane / 16 h / 20 °C

9.1: sodium hydroxide / water; tetrahydrofuran / 16 h / 20 °C

9.2: pH 6

10.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 3 h / 20 °C / Inert atmosphere

With dmap; di-tert-butyl dicarbonate; hydrogen; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; industrial methylated spirits; diethyl ether; 2-Methylpentane; dichloromethane; industrial methylated spritis; water; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol; toluene;

Reference yield:

: 951127-26-7
1-(2,5-difluorophenyl)-2-nitroethanol

: 1376609-97-0
{(3R,4S)-4-(2,5-difluorophenyl)-1-[5-({1-[3-(1-fluoro-1-methylethyl)[1,2,4]oxadiazol-5-yl]piperidin-4-yl}(methyl)carbamoyl)pyrimidin-2-yl]pyrrolidin-3-yl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap / 18 h / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / -5 - 30 °C

3.1: hydrogen / RaNi / industrial methylated spritis / 18 h / 20 °C / 37503.8 Torr / Autoclave

4.1: di-tert-butyl dicarbonate / tetrahydrofuran / 18 h / 0 - 20 °C

5.1: isopropyl alcohol; diethyl ether; 2-Methylpentane / Resolution of racemate; Autoclave

6.1: hydrogen / palladium 10% on activated carbon / toluene; industrial methylated spirits / 78 h / 20 - 60 °C

7.1: triethylamine / 1,2-dichloro-ethane / 16 h / 20 °C

8.1: sodium hydroxide / water; tetrahydrofuran / 16 h / 20 °C

8.2: pH 6

9.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 3 h / 20 °C / Inert atmosphere

With dmap; di-tert-butyl dicarbonate; hydrogen; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; industrial methylated spirits; diethyl ether; 2-Methylpentane; dichloromethane; industrial methylated spritis; water; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol; toluene;