TSH

Base Information

• Chemical Name: TSH
• CAS No.: 9002-71-5
• Molecular Weight: 0

Synonyms:Dermathycin;Pretiron; TSH; TSH (hormone); TTH; Thyreotrophic hormone; Thyroid-stimulatingfactor; Thyroid-stimulating hormone; Thyrotrophin; Thyrotropic hormone;Thytropar

Chemical Property of TSH

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

TSH ^*data from reagent suppliers

Safty Information:

• Hazard Codes: B

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Biological functions: TSH derived from the pars distalis of the pituitary binds to the TSHR located on the membrane of thyroid follicular cells. TSH stimulates thyroid hormone production, iodine uptake and organification, and thyroid growth. TSH derived from the pars tuberalis of the pituitary binds to the TSHR in the ependymal cells and induces the expression of type 2 deiodinase (Dio2), which converts T4 into bioactive T3. This leads to seasonal reproduction. TSHR is also expressed in a variety of extrathyroidal tissues including fat, fibroblasts, bone, and cardiomyocytes.
• Uses: Thyrogen (Genzyme). Thyrotropic hormone from porcine pituitary can be used as a NCTC-135 medium supplement for isolating the thyroid cells which in turn is used for studying the impact of retinoids on non-transformed cells like thyrocytes. The product can also be used in cell proliferation experiment for studying the impact of increased IGF binding proteins 1 level on the function and growth of the thyroid gland in transgenic mice.
• Indications: TSH, or thyrotropin, is a glycosylated protein of two subunits,  and . TSH stimulates the thyroid gland to produce thyroid hormones. Deficiencies are treated by giving thyroxine itself rather than TSH, but TSH is available for diagnostic purposes to differentiate between pituitary and thyroid gland failure as causes of hypothyroidism.
• Clinical Use: Recombinant form of human thyroidstimulating hormone (rhTSH). Used diagnostically for serum thyroglobulin testing. TSH levels are measured as part of a thyroid function test in patients suspected of hyperthyroidism and hypothyroidism as the simplest and most sensitive indicator. Primary hypothyroidism/hypothyroidism is characterized by a high/low serum TSH concentration and a low/high serum free T4 concentration. Subclinical hypothyroidism/hypothyroidism is defined biochemically as a normal free T4 concentration in the presence of an increased/decreased TSH concentration. Central hypothyroidism is characterized by a low serum T4 concentration and a low or normal serum TSH concentration, whereas TSH-secreting pituitary adenomas may lead to the development of hyperthyroidism through a condition called the syndrome of the inappropriate secretion of TSH (SITSH). Recombinant human TSH is used in the follow up of patients with thyroid cancer to ablate the thyroid remnant following thyroid cancer surgery, and to obtain reliable diagnostic test results for the recurrence of differentiated thyroid cancer.

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