Technology Process of 1-[2-(4-amino-3-chlorobenzoylamino)-3,3-dimethylbutyryl]pyrrolidine-2-carboxylic acid tert-butyl ester
There total 4 articles about 1-[2-(4-amino-3-chlorobenzoylamino)-3,3-dimethylbutyryl]pyrrolidine-2-carboxylic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
DOI:10.1002/cmdc.200900531
- Guidance literature:
-
Multi-step reaction with 2 steps
1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 18 h
2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 18.67 h / 0 - 20 °C
With
palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydrogencarbonate / water / 21 h / 0 - 20 °C
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 5.17 h / 0 - 20 °C
3: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 18 h
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 18.67 h / 0 - 20 °C
With
palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
