N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-benzyloxymethyl-5-hydroxy-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

Base Information

Chemical Name:N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-benzyloxymethyl-5-hydroxy-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide
CAS No.:178986-36-2
Molecular Formula:C₃₇H₄₉NO₈
Molecular Weight:635.798
Hs Code.:

Synonyms:N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-benzyloxymethyl-5-hydroxy-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-benzyloxymethyl-5-hydroxy-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-benzyloxymethyl-5-hydroxy-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

There total 7 articles about N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-benzyloxymethyl-5-hydroxy-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 178986-35-1
N-{(2R,4aR,6R,7R,8R,8aS)-8-Benzyloxy-6-[8-(4-methoxy-phenoxy)-octyloxy]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl}-acetamide

: 178986-36-2
N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-benzyloxymethyl-5-hydroxy-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

Guidance literature:: With hydrogenchloride; 3 A molecular sieve; sodium cyanoborohydride; In tetrahydrofuran;
DOI:10.1016/0968-0896(96)00064-8

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 178986-36-2
N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-benzyloxymethyl-5-hydroxy-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / p-toluenesulfonic acid / dimethylformamide / 3 h / 60 °C

2: 91 percent / BaO, Ba(OH)2 / dimethylformamide / 12 h / Ambient temperature

3: 70 percent / NaCNBH₃, 3 A molecular sieves, satd. HCl in Et₂O / tetrahydrofuran

With hydrogenchloride; barium dihydroxide; 3 A molecular sieve; sodium cyanoborohydride; toluene-4-sulfonic acid; barium(II) oxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/0968-0896(96)00064-8

Reference yield:

: 121692-14-6
8-p-methoxyphenoxyloctanol

: 178986-36-2
N-{(2R,3R,4R,5S,6R)-4-Benzyloxy-6-benzyloxymethyl-5-hydroxy-2-[8-(4-methoxy-phenoxy)-octyloxy]-tetrahydro-pyran-3-yl}-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Hg(CN)2, CaSO₄ / 1.) toluene, RT, 1 h, 2.) toluene, 4 d

2: NaOMe, MeOH / 24 h / Ambient temperature

3: 94 percent / p-toluenesulfonic acid / dimethylformamide / 3 h / 60 °C

4: 91 percent / BaO, Ba(OH)2 / dimethylformamide / 12 h / Ambient temperature

5: 70 percent / NaCNBH₃, 3 A molecular sieves, satd. HCl in Et₂O / tetrahydrofuran

With hydrogenchloride; methanol; calcium sulfate; barium dihydroxide; 3 A molecular sieve; sodium methylate; mercury(II) cyanide; sodium cyanoborohydride; toluene-4-sulfonic acid; barium(II) oxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/0968-0896(96)00064-8