1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-3-[3-(4-{5-methoxy-6-[N-methyl(phenylsulfonyl)amino](2-pyridyl)}phenyl)propyl]-4,5-dihydro-1H-1,2,4-triazolin-5-one

Base Information

Chemical Name:1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-3-[3-(4-{5-methoxy-6-[N-methyl(phenylsulfonyl)amino](2-pyridyl)}phenyl)propyl]-4,5-dihydro-1H-1,2,4-triazolin-5-one
CAS No.:1454926-60-3
Molecular Formula:C₃₇H₄₃N₅O₄S
Molecular Weight:653.846
Hs Code.:

1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-3-[3-(4-{5-methoxy-6-[N-methyl(phenylsulfonyl)amino](2-pyridyl)}phenyl)propyl]-4,5-dihydro-1H-1,2,4-triazolin-5-one

Synonyms:1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-3-[3-(4-{5-methoxy-6-[N-methyl(phenylsulfonyl)amino](2-pyridyl)}phenyl)propyl]-4,5-dihydro-1H-1,2,4-triazolin-5-one

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Chemical Property of 1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-3-[3-(4-{5-methoxy-6-[N-methyl(phenylsulfonyl)amino](2-pyridyl)}phenyl)propyl]-4,5-dihydro-1H-1,2,4-triazolin-5-one

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Technology Process of 1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-3-[3-(4-{5-methoxy-6-[N-methyl(phenylsulfonyl)amino](2-pyridyl)}phenyl)propyl]-4,5-dihydro-1H-1,2,4-triazolin-5-one

There total 12 articles about 1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-3-[3-(4-{5-methoxy-6-[N-methyl(phenylsulfonyl)amino](2-pyridyl)}phenyl)propyl]-4,5-dihydro-1H-1,2,4-triazolin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1454926-08-9
1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-3-[3-(4-{5-methoxy-6-[(phenylsulfonyl)amino](2-pyridyl)}phenyl)propyl]-4,5-dihydro-1H-1,2,4-triazolin-5-one

: 74-88-4
methyl iodide

: 1454926-60-3
1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-3-[3-(4-{5-methoxy-6-[N-methyl(phenylsulfonyl)amino](2-pyridyl)}phenyl)propyl]-4,5-dihydro-1H-1,2,4-triazolin-5-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1454926-07-8
3-{3-[4-(6-amino-5-methoxy-(2-pyridyl))phenyl]propyl}-1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-4,5-dihydro-1H-1,2,4-triazolin-5-one

: 1454926-60-3
1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-3-[3-(4-{5-methoxy-6-[N-methyl(phenylsulfonyl)amino](2-pyridyl)}phenyl)propyl]-4,5-dihydro-1H-1,2,4-triazolin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 24 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With pyridine; potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 1454928-51-8
3-(3-(4-bromophenyl)propyl)-1-(4-tert-butylbenzyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one

: 1454926-60-3
1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-3-[3-(4-{5-methoxy-6-[N-methyl(phenylsulfonyl)amino](2-pyridyl)}phenyl)propyl]-4,5-dihydro-1H-1,2,4-triazolin-5-one

Guidance literature:: Multi-step reaction with 5 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 12 h / 85 °C / Inert atmosphere

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 24 h / 85 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 16 h / 20 °C / Inert atmosphere

4: pyridine / 24 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium acetate; potassium carbonate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide;