N-[(1S)-1-[[[(1R)-1-[(3aS,4R,6R,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-amino]carbonyl]-2-phenyl]-2-pyrazincarboxamide

Base Information

Chemical Name:N-[(1S)-1-[[[(1R)-1-[(3aS,4R,6R,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-amino]carbonyl]-2-phenyl]-2-pyrazincarboxamide
CAS No.:1621908-72-2
Molecular Formula:C₂₉H₃₉BN₄O₄
Molecular Weight:518.464
Hs Code.:

N-[(1S)-1-[[[(1R)-1-[(3aS,4R,6R,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-amino]carbonyl]-2-phenyl]-2-pyrazincarboxamide

Synonyms:N-[(1S)-1-[[[(1R)-1-[(3aS,4R,6R,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-amino]carbonyl]-2-phenyl]-2-pyrazincarboxamide

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Chemical Property of N-[(1S)-1-[[[(1R)-1-[(3aS,4R,6R,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-amino]carbonyl]-2-phenyl]-2-pyrazincarboxamide

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Technology Process of N-[(1S)-1-[[[(1R)-1-[(3aS,4R,6R,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-amino]carbonyl]-2-phenyl]-2-pyrazincarboxamide

There total 4 articles about N-[(1S)-1-[[[(1R)-1-[(3aS,4R,6R,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-amino]carbonyl]-2-phenyl]-2-pyrazincarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: C₁₅H₂₈BNO₂*C₂HF₃O₂

: 114457-94-2,1608986-16-8
(S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid

: 1621908-72-2
N-[(1S)-1-[[[(1R)-1-[(3aS,4R,6R,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-amino]carbonyl]-2-phenyl]-2-pyrazincarboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;
DOI:10.3390/molecules181215398

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1621908-72-2
N-[(1S)-1-[[[(1R)-1-[(3aS,4R,6R,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-amino]carbonyl]-2-phenyl]-2-pyrazincarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 16 h / 20 °C

2: dichloromethane / 16.5 h / -40 - 20 °C

3: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/molecules181215398

Reference yield:

: 98-97-5
2-pyrazylcarboxylic acid

: 1621908-72-2
N-[(1S)-1-[[[(1R)-1-[(3aS,4R,6R,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]-amino]carbonyl]-2-phenyl]-2-pyrazincarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 16 h / 20 °C

2: dichloromethane / 16.5 h / -40 - 20 °C

3: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/molecules181215398