N-(Trimethylsilyl)-L-phenylalanine trimethylsilyl ester

Base Information

• Chemical Name: N-(Trimethylsilyl)-L-phenylalanine trimethylsilyl ester
• CAS No.: 7364-51-4
• Molecular Formula: C15H27NO2Si2
• Molecular Weight: 309.556
• Mol file: 7364-51-4.mol

Synonyms:N,O-bis(trimethylsilyl)phenylalanine;N,O-bis(trimethylsilyl)-L-phenylalanine;N-trimethylsilanyl-L-phenylalanine trimethylsilanyl ester;

Chemical Property of N-(Trimethylsilyl)-L-phenylalanine trimethylsilyl ester

Chemical Property:

• PSA: 38.33000
• LogP: 3.79120

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(Trimethylsilyl)-L-phenylalanine trimethylsilyl ester

There total 5 articles about N-(Trimethylsilyl)-L-phenylalanine trimethylsilyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,O-bis-(trimethylsilyl)-acetamide (10416-59-8) + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → N,O-bis(trimethylsilyl)phenylalanine (7364-51-4)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1016/j.tet.2009.06.042

Reference yield:

chloro-trimethyl-silane (75-77-4) + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → N,O-bis(trimethylsilyl)phenylalanine (7364-51-4)

Guidance literature:

In dichloromethane; for 1h; Heating;

DOI:10.1021/ja970709e

Reference yield:

trimethylsilyl cyanide (7677-24-9) + L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → N,O-bis(trimethylsilyl)phenylalanine (7364-51-4)

Guidance literature:

With triethylamine;

upstream raw materials:

L-phenylalanine

1,1,1,3,3,3-hexamethyl-disilazane

trimethylsilyl trifluoromethanesulfonate

chloro-trimethyl-silane

Downstream raw materials:

(2Ξ,4S)-4-benzyl-2-trichloromethyl-oxazolidin-5-one

Trt-Phe*Et₂NH

4-(phenylacetoxy)benzyl-L-phenylalanine

(S)-3-phenyl-2[(pyrazine-2-carbonyl)-amino]propionic acid

Refernces

• 1、 Surcshbabu, Vommina V.,Sudarshan,Chennakrishnareddy. "Simple and rapid synthesis of Nα-urethane protected β-amino alcohols and peptide alcohols employing HATU". experimental part. p. 574 - 579. Retrieved 2009/12/06.
• 2、 Sureshbabu, Vommina V.,Sudarshan, Naremaddepalli S.,Kantharaju. "Efficient synthesis of O-succinimidyl-(tert-butoxycarbonylamino)methyl carbamates derived from α-amino acids accelerated by ultrasound: Application to the synthesis of ureidodipeptides". . p. 2168 - 2184. Retrieved 2008/09/21.