(R)-1-((4R,5R)-5-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol

Base Information

Chemical Name:(R)-1-((4R,5R)-5-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol
CAS No.:1392302-11-2
Molecular Formula:C₁₆H₂₄O₄
Molecular Weight:280.364
Hs Code.:

Synonyms:(R)-1-((4R,5R)-5-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol

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Chemical Property of (R)-1-((4R,5R)-5-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol

Chemical Property:

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Technology Process of (R)-1-((4R,5R)-5-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol

There total 7 articles about (R)-1-((4R,5R)-5-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₃₀O₇S

: 1392302-11-2
(R)-1-((4R,5R)-5-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol

Guidance literature:: C₂₃H₃₀O₇S; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; at 0 ℃;
DOI:10.1016/j.tetasy.2012.06.021

Reference yield:

: 4239-90-1,22893-94-3
(4S,4'R,5R)-2,2,2',2'-tetramethyl-5-vinyl-4,4'-bi(1,3-dioxolane)

: 1392302-11-2
(R)-1-((4R,5R)-5-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere

2.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

3.2: 3 h / 0 - 20 °C / Inert atmosphere

4.1: methanol; pyridinium p-toluenesulfonate / 0 - 20 °C

5.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

5.2: 3 h / 0 - 20 °C / Inert atmosphere

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

6.2: 0 °C

With methanol; lithium aluminium tetrahydride; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; di(n-butyl)tin oxide; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2012.06.021

Reference yield:

: C₂₀H₃₅BO₄

: 1392302-11-2
(R)-1-((4R,5R)-5-(2-(benzyloxy)ethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

2.2: 3 h / 0 - 20 °C / Inert atmosphere

3.1: methanol; pyridinium p-toluenesulfonate / 0 - 20 °C

4.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 0.25 h / 0 - 20 °C / Inert atmosphere

4.2: 3 h / 0 - 20 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

5.2: 0 °C

With methanol; lithium aluminium tetrahydride; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; di(n-butyl)tin oxide; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2012.06.021