Technology Process of 4-<2-(Diethylamino)ethoxy>-1,2-dimethyl-1,4-cyclohexadien
There total 2 articles about 4-<2-(Diethylamino)ethoxy>-1,2-dimethyl-1,4-cyclohexadien which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonia; lithium;
In
diethyl ether; tert-butyl alcohol;
at -45 ℃;
for 2h;
Yield given;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) 80percent NaOH / 1.) paraffin oil, toluene, 30 min, reflux, 2.) toluene, 4 h, reflux
2: 61 percent / NH3, Li / 2-methyl-propan-2-ol; diethyl ether / 2 h / -45 °C
With
sodium hydroxide; ammonia; lithium;
In
diethyl ether; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) 15percent BuLi / 1.) n-hexane, THF, -80 deg C, 15 min, 2.) HMPA, -70 deg C
2: 6 N HCl / acetone / 2 h / 0 deg C up to room temp.
3: 94 percent / p-toluenesulfonic acid / diethyl ether / 2 h / Ambient temperature
4: 94 percent / LiAlH4 / diethyl ether / 1 h / Ambient temperature
5: 92 percent / KOH / dimethylsulfoxide / 2 h / Ambient temperature
6: 77 percent Turnov. / NH3, Li / diethyl ether / 1 h / -45 °C
7: 96 percent / 1N HCl / ethanol / 1 h / 50 °C
8: 73 percent / Jones-reagent (CrO3) / acetone / 0 °C
With
chromium(VI) oxide; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; ammonia; lithium;
toluene-4-sulfonic acid;
In
diethyl ether; ethanol; dimethyl sulfoxide; acetone;
