ethyl 1-(4-chlorophenyl)-5-(2-methoxy-2-oxoethyl)-4-methyl-1H-pyrazole-3-carboxylate

Base Information

• Chemical Name: ethyl 1-(4-chlorophenyl)-5-(2-methoxy-2-oxoethyl)-4-methyl-1H-pyrazole-3-carboxylate
• CAS No.: 1421357-54-1
• Molecular Formula: C₁₆H₁₇ClN₂O₄
• Molecular Weight: 336.775
• Mol file: 1421357-54-1.mol

Synonyms:ethyl 1-(4-chlorophenyl)-5-(2-methoxy-2-oxoethyl)-4-methyl-1H-pyrazole-3-carboxylate

Chemical Property of ethyl 1-(4-chlorophenyl)-5-(2-methoxy-2-oxoethyl)-4-methyl-1H-pyrazole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 1-(4-chlorophenyl)-5-(2-methoxy-2-oxoethyl)-4-methyl-1H-pyrazole-3-carboxylate

There total 5 articles about ethyl 1-(4-chlorophenyl)-5-(2-methoxy-2-oxoethyl)-4-methyl-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 2-(N-(4-methylphenyl)hydrazono)acetate → ethyl 1-(4-chlorophenyl)-5-(2-methoxy-2-oxoethyl)-4-methyl-1H-pyrazole-3-carboxylate (1421357-54-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo302696y

Reference yield:

C22H33ClN2O5Si → ethyl 1-(4-chlorophenyl)-5-(2-methoxy-2-oxoethyl)-4-methyl-1H-pyrazole-3-carboxylate (1421357-54-1) + (E)-1-ethyl 6-methyl 2-[2-(4-chlorophenyl)hydrazono]-3-methyl-4-oxohexanedioate (1421357-66-5)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/jo302696y

Reference yield:

p-tolylhydrazine hydrochloride (637-60-5,35467-65-3) → ethyl 1-(4-chlorophenyl)-5-(2-methoxy-2-oxoethyl)-4-methyl-1H-pyrazole-3-carboxylate (1421357-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / Inert atmosphere

1.2: 12.5 h / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo302696y

upstream raw materials:

4-chlorophenylhydrazine hydrochloride

ethyl 2-(2-(4-chlorophenyl)hydrazono)acetate

p-tolylhydrazine hydrochloride