(4-Chloroanilino)azanium;chloride

Base Information

• Chemical Name: (4-Chloroanilino)azanium;chloride
• CAS No.: 1073-70-7
• Molecular Formula: C6H7ClN2^.HCl
• Molecular Weight: 179.049
• Hs Code.: 29280090
• Mol file: 1073-70-7.mol

Synonyms:(4-chloroanilino)azanium;chloride;AKOS023093328

Chemical Property of (4-Chloroanilino)azanium;chloride

Chemical Property:

• Appearance/Colour: white to pink crystalline powder
• Melting Point: 216 °C (dec.)(lit.)
• Boiling Point: 265.3 °C at 760 mmHg
• Flash Point: 114.2 °C
• PSA: 38.05000
• Density: 1.32 g/cm³
• LogP: 3.20090
• Storage Temp.: Store below +30°C.
• Solubility.: soluble in Methanol
• Water Solubility.: Soluble in hot water, methanol.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 178.0064537
• Heavy Atom Count: 10
• Complexity: 79.1

Purity/Quality:

98% ^*data from raw suppliers

4-Chlorophenylhydrazine HCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 36/37-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1N[NH3+])Cl.[Cl-]
• Uses: 4-Chlorophenylhydrazine hydrochloride is used as a pharmaceutical intermediates.

Technology Process of (4-Chloroanilino)azanium;chloride

There total 9 articles about (4-Chloroanilino)azanium;chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

p-chlorobenzenediazonium chloride (2028-74-2) → 4-chlorophenylhydrazine hydrochloride (1073-70-7)

Guidance literature:

With 5% active carbon-supported ruthenium; hydrogen; at 30 ℃; for 4h; under 3750.38 Torr; Temperature; Pressure; Reagent/catalyst;

Reference yield: 90.0%

3-(4-chlorophenyl)sydnone (829-31-2) → 4-chlorophenylhydrazine hydrochloride (1073-70-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 60 ℃; for 0.25h;

DOI:10.1002/jccs.200000027

Reference yield: 88.3%

4-chloro-aniline (106-47-8) → 4-chlorophenylhydrazine hydrochloride (1073-70-7)

Guidance literature:

4-chloro-aniline; With hydrogenchloride; sodium nitrite; In water; for 1h;

With sodium sulfite; at 80 ℃; for 2.5h;

With hydrogenchloride; In water; at 95 ℃; for 2h;

upstream raw materials:

4-chloro-aniline

ethanol

4-chloro-3-(4-chlorophenyl)sydnone

3-(4-chlorophenyl)sydnone

Downstream raw materials:

3-Chloro-4-methoxy-benzoic acid N'-(4-chloro-phenyl)-hydrazide

4-chloro-N'-(4-chlorophenyl) benzohydrazide

N-(4-Chloro-phenyl)-N'-[(E)-3-furan-2-yl-prop-2-en-(E)-ylidene]-hydrazine

dehydroacetic acid (4-chlorophenyl)hydrazone

Refernces

• 1、 Lombardi, Lorenzo,Bellini, Daniele,Bottoni, Andrea,Calvaresi, Matteo,Monari, Magda,Kovtun, Alessandro,Palermo, Vincenzo,Melucci, Manuela,Bandini, Marco. "Allylic and Allenylic Dearomatization of Indoles Promoted by Graphene Oxide by Covalent Grafting Activation Mode". . p. 10427 - 10432. Retrieved 2020.
• 2、 Zhai, Min'an,Wang, Long,Liu, Shiyuan,Wang, Lijing,Yan, Peng,Wang, Junfang,Zhang, Jingbo,Guo, Haifei,Guan, Qi,Bao, Kai,Wu, Yingliang,Zhang, Weige. "Synthesis and biological evaluation of (1-aryl-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone derivatives as tubulin inhibitors". . p. 137 - 147. Retrieved 2018.
• 3、 Mendes, Mylla Cristie Da Silva,Fazolo, Bruno Rodrigues,De Souza, Jéssica Maria,De Vasconcelos, Leonardo Gomes,De Sousa Junior, Paulo Teixeira,Dall'Oglio, Evandro Luiz,Soares, Marcos Ant?nio,Sampaio, Olívia Moreira,Vieira, Lucas Campos Curcino. "Synthesis and evaluation of indole derivatives as photosynthesis and plant growth inhibitors". . p. 1350 - 1358. Retrieved 2019.
• 4、 Kotha, Sambasivarao,Saifuddin, Mohammad,Aswar, Vikas R.. "A diversity-oriented approach to indolocarbazoles: Via Fischer indolization and olefin metathesis: Total synthesis of tjipanazole D and i". . p. 9868 - 9873. Retrieved 2016.
• 5、 -. "Synthesis method of metolachlor intermediate". Paragraph 0078-0088; 0097-0107. . Retrieved 2021/09/21.