[2,7-Dichloro-5,8-dimethoxy-4-(2-nitro-phenyl)-quinolin-6-yl]-acetonitrile

Base Information

Chemical Name:[2,7-Dichloro-5,8-dimethoxy-4-(2-nitro-phenyl)-quinolin-6-yl]-acetonitrile
CAS No.:156489-11-1
Molecular Formula:C₁₉H₁₃Cl₂N₃O₄
Molecular Weight:418.236
Hs Code.:

Synonyms:[2,7-Dichloro-5,8-dimethoxy-4-(2-nitro-phenyl)-quinolin-6-yl]-acetonitrile

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Chemical Property of [2,7-Dichloro-5,8-dimethoxy-4-(2-nitro-phenyl)-quinolin-6-yl]-acetonitrile

Chemical Property:

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Technology Process of [2,7-Dichloro-5,8-dimethoxy-4-(2-nitro-phenyl)-quinolin-6-yl]-acetonitrile

There total 3 articles about [2,7-Dichloro-5,8-dimethoxy-4-(2-nitro-phenyl)-quinolin-6-yl]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 156489-10-0
[2,7-Dichloro-5,8-dimethoxy-4-(2-nitro-phenyl)-quinolin-6-yl]-acetaldehyde

: 156489-11-1
[2,7-Dichloro-5,8-dimethoxy-4-(2-nitro-phenyl)-quinolin-6-yl]-acetonitrile

Guidance literature:: With pyridine; aminosulfonic acid; In ethanol;
DOI:10.1021/jo00092a002

Reference yield:

: 156489-09-7
2-[2,7-Dichloro-5,8-dimethoxy-4-(2-nitro-phenyl)-quinolin-6-yl]-ethanol

: 156489-11-1
[2,7-Dichloro-5,8-dimethoxy-4-(2-nitro-phenyl)-quinolin-6-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / SO₃*Pyr / dimethylsulfoxide

2: 83 percent / H₂NSO₃H, pyridine / ethanol

With pyridine; pyridine-SO₃ complex; aminosulfonic acid; In ethanol; dimethyl sulfoxide;
DOI:10.1021/jo00092a002

Reference yield:

: 156489-08-6
Acetic acid 2-[2,7-dichloro-5,8-dimethoxy-4-(2-nitro-phenyl)-quinolin-6-yl]-ethyl ester

: 156489-11-1
[2,7-Dichloro-5,8-dimethoxy-4-(2-nitro-phenyl)-quinolin-6-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: aq. K₂CO₃ / tetrahydrofuran; methanol

2: 81 percent / SO₃*Pyr / dimethylsulfoxide

3: 83 percent / H₂NSO₃H, pyridine / ethanol

With pyridine; pyridine-SO₃ complex; aminosulfonic acid; potassium carbonate; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide;
DOI:10.1021/jo00092a002