ethyl N-{4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}glycinate

Base Information

• Chemical Name: ethyl N-{4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}glycinate
• CAS No.: 439612-12-1
• Molecular Formula: C₂₃H₂₈N₂O₃
• Molecular Weight: 380.487
• Mol file: 439612-12-1.mol

Synonyms:ethyl N-{4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}glycinate

Chemical Property of ethyl N-{4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}glycinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl N-{4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}glycinate

There total 5 articles about ethyl N-{4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.5%

→ ethyl N-{4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}glycinate (439612-12-1)

Guidance literature:

Reference yield:

ethyl bromoacetate (105-36-2) + 4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-dimethyl-phenylamine (361435-56-5) → ethyl N-{4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}glycinate (439612-12-1)

Guidance literature:

With sodium acetate; In ethanol; water;

Reference yield:

3-isopropyl-1H-indol-5-ol (361436-24-0) → ethyl N-{4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}glycinate (439612-12-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / water; dimethyl sulfoxide; ethyl acetate

2: palladium/active carbon / methanol; ethanol

3: sodium acetate / ethanol; water

With sodium acetate; potassium carbonate; palladium/active carbon; In methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate;

upstream raw materials:

ethyl bromoacetate

4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-dimethyl-phenylamine

2-fluoro-1,3-dimethyl-5-nitrobenzene

3-isopropyl-1H-indol-5-ol

Downstream raw materials:

N-{4-[(3-Isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}glycine