(RS)-[(SR)-benzo[1,3]dioxol-5-yl-(3,4,5-trimethoxy-phenyl)-methyl]-succinic acid

Base Information

• Chemical Name: (RS)-[(SR)-benzo[1,3]dioxol-5-yl-(3,4,5-trimethoxy-phenyl)-methyl]-succinic acid
• CAS No.: 102448-75-9
• Molecular Formula: C₂₁H₂₂O₉
• Molecular Weight: 418.4
• Mol file: 102448-75-9.mol

Synonyms:(RS)-[(SR)-benzo[1,3]dioxol-5-yl-(3,4,5-trimethoxy-phenyl)-methyl]-succinic acid

Chemical Property of (RS)-[(SR)-benzo[1,3]dioxol-5-yl-(3,4,5-trimethoxy-phenyl)-methyl]-succinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (RS)-[(SR)-benzo[1,3]dioxol-5-yl-(3,4,5-trimethoxy-phenyl)-methyl]-succinic acid

There total 3 articles about (RS)-[(SR)-benzo[1,3]dioxol-5-yl-(3,4,5-trimethoxy-phenyl)-methyl]-succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((E)-3,4,5-trimethoxy-3',4'-methylenedioxy-benzhydrylidene)-succinic acid (102474-37-3) → (RS)-[(SR)-benzo[1,3]dioxol-5-yl-(3,4,5-trimethoxy-phenyl)-methyl]-succinic acid (102448-75-9)

Guidance literature:

With ethanol; palladium; at 60 ℃; Hydrogenation;

DOI:10.1021/ja01630a111

Reference yield:

benzo[1,3]dioxol-5-yl-(3,4,5-trimethoxy-phenyl)-methanone (6327-54-4) → (RS)-[(SR)-benzo[1,3]dioxol-5-yl-(3,4,5-trimethoxy-phenyl)-methyl]-succinic acid (102448-75-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate; tert-butyl alcohol / Erwaermen des Reaktionsprodukts mit wss.-methanol. Natronlauge

2: palladium; ethanol / 60 °C / Hydrogenation

With ethanol; potassium tert-butylate; palladium; tert-butyl alcohol;

DOI:10.1021/ja01630a111

Reference yield:

→ [benzo[1,3]dioxol-5-yl-(3,4,5-trimethoxy-phenyl)-methyl]-succinic acid (102448-75-9)

Guidance literature:

3.4-Methylendioxy-3'.4'.5'-trimethoxydiphenyl-itaconsaeure A, Hydrieren an Pd/C, abs. Ethanol, 60grad;

DOI:10.1021/ja01492a047

upstream raw materials:

((E)-3,4,5-trimethoxy-3',4'-methylenedioxy-benzhydrylidene)-succinic acid

benzo[1,3]dioxol-5-yl-(3,4,5-trimethoxy-phenyl)-methanone