JNJ-632

Base Information

• Chemical Name: JNJ-632
• CAS No.: 1572510-42-9
• Molecular Formula: C₁₈H₁₉FN₂O₄S
• Molecular Weight: 378.424

Synonyms:N-(4-fluoro-3-methylphenyl)-3-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]benzamide

Chemical Property of JNJ-632

Chemical Property:

• PKA: 10.37±0.20(Predicted)
• Density: 1.39±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

JNJ-632 >98% ^*data from reagent suppliers

Safty Information:

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Technology Process of JNJ-632

There total 7 articles about JNJ-632 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chlorosulfonylbenzoyl dichloride (4052-92-0) + 3-methyl-4-fluoroaniline (452-69-7) + (S)-tetrahydrofuran-3-yl-amine (104530-79-2,111769-26-7) → N-(4-fluoro-3-methylphenyl)-3-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]benzamide (1572510-42-9)

Guidance literature:

3-chlorosulfonylbenzoyl dichloride; 3-methyl-4-fluoroaniline; With triethylamine; In dichloromethane; at 0 - 25 ℃;

(S)-tetrahydrofuran-3-yl-amine; In dichloromethane; at 0 - 25 ℃;

Reference yield:

3-chlorosulfonylbenzoyl dichloride (4052-92-0) + 3-methyl-4-fluoroaniline (452-69-7) + (S)-(-)-tetrahydro-3-furylamine p-toluenesulfonate salt (104530-80-5) → N-(4-fluoro-3-methylphenyl)-3-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]benzamide (1572510-42-9)

Guidance literature:

3-chlorosulfonylbenzoyl dichloride; 3-methyl-4-fluoroaniline; In toluene; Reflux;

(S)-(-)-tetrahydro-3-furylamine p-toluenesulfonate salt; With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; at 20 ℃; for 4h;

Reference yield:

3-chlorosulfonylbenzoyl dichloride (4052-92-0) + 3-methyl-4-fluoroaniline (452-69-7) + (S)-(-)-tetrahydro-3-furylamine p-toluenesulfonate salt (104530-80-5) → N-(4-fluoro-3-methylphenyl)-3-[[(3S)-tetrahydrofuran-3-yl]sulfamoyl]benzamide (1572510-42-9) + 3-(4-fluoro-3-methylphenylcarbamoyl)benzene-1-sulfonyl chloride (1572515-74-2)

Guidance literature:

3-chlorosulfonylbenzoyl dichloride; 3-methyl-4-fluoroaniline; In toluene; for 0.5h; Reflux; Inert atmosphere;

(S)-(-)-tetrahydro-3-furylamine p-toluenesulfonate salt; With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; at 20 ℃; for 4h;

upstream raw materials:

3-chlorosulfonylbenzoyl dichloride

3-methyl-4-fluoroaniline

(S)-tetrahydrofuran-3-yl-amine

(S)-(-)-tetrahydro-3-furylamine p-toluenesulfonate salt

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