(5α,11β,16α,17β)-11-(4-bromophenyl)-17-(cyclopropylcarbonyl)-5-hydroxy-16-methylestr-9-en-3-one cyclic 1,2-ethanediyl acetal

Base Information

Chemical Name:(5α,11β,16α,17β)-11-(4-bromophenyl)-17-(cyclopropylcarbonyl)-5-hydroxy-16-methylestr-9-en-3-one cyclic 1,2-ethanediyl acetal
CAS No.:866004-33-3
Molecular Formula:C₃₁H₃₉BrO₄
Molecular Weight:555.552
Hs Code.:

Synonyms:(5α,11β,16α,17β)-11-(4-bromophenyl)-17-(cyclopropylcarbonyl)-5-hydroxy-16-methylestr-9-en-3-one cyclic 1,2-ethanediyl acetal

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Chemical Property of (5α,11β,16α,17β)-11-(4-bromophenyl)-17-(cyclopropylcarbonyl)-5-hydroxy-16-methylestr-9-en-3-one cyclic 1,2-ethanediyl acetal

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Technology Process of (5α,11β,16α,17β)-11-(4-bromophenyl)-17-(cyclopropylcarbonyl)-5-hydroxy-16-methylestr-9-en-3-one cyclic 1,2-ethanediyl acetal

There total 2 articles about (5α,11β,16α,17β)-11-(4-bromophenyl)-17-(cyclopropylcarbonyl)-5-hydroxy-16-methylestr-9-en-3-one cyclic 1,2-ethanediyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 866004-32-2
(5α,10α,16α,17β)-17-(cyclopropylcarbonyl)-5,10-epoxy-16-methylestr-9(11)-en-3-one cyclic 1,2-ethanediyl acetal

: 106-37-6
1.4-dibromobenzene

: 866004-33-3
(5α,11β,16α,17β)-11-(4-bromophenyl)-17-(cyclopropylcarbonyl)-5-hydroxy-16-methylestr-9-en-3-one cyclic 1,2-ethanediyl acetal

Guidance literature:: 1.4-dibromobenzene; With magnesium; iodine; ethylene dibromide; In tetrahydrofuran; at 45 ℃; for 1h;

(5α,10α,16α,17β)-17-(cyclopropylcarbonyl)-5,10-epoxy-16-methylestr-9(11)-en-3-one cyclic 1,2-ethanediyl acetal; With copper(l) chloride; In tetrahydrofuran; at -40 - 20 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: C₂₅H₃₄O₄

: 106-37-6
1.4-dibromobenzene

: 866004-33-3
(5α,11β,16α,17β)-11-(4-bromophenyl)-17-(cyclopropylcarbonyl)-5-hydroxy-16-methylestr-9-en-3-one cyclic 1,2-ethanediyl acetal

Guidance literature:: 1.4-dibromobenzene; With iodine; magnesium; ethylene dibromide; In tetrahydrofuran; at 45 ℃; for 2h;

C₂₅H₃₄O₄; copper(l) chloride; In tetrahydrofuran; at -40 - 20 ℃; for 2h; Further stages.;
DOI:10.1016/j.bmc.2008.01.010